Safety and efficacy of laser-induced thrombolysis in thromboembolism of major cerebral arteries - Safety and efficacy of laser-induced thrombolysis

Hamamatsu univeristy hospital0 个研究点目标入组 3 人开始时间: 2016年11月1日最近更新: 2023年10月17日

适应症

试验速览

暂无简介。

•1. Treatment by intravenous t-PA administration within 12 weeks of IC 2. Sudden improvement of symptom of stroke 3. NIHSS score > 24 or coma 4. Women with pregnancy (possible), or lactating 5. Impossible access for vessels 6. Bleeding, in the tendency to bleeding, and family history and past history of bleeding disorders 7. Treatment of oral coagulant and PT-INR > 3.0 8. 9. APTT twice more than upper limit of normal. 10. Platelet count < 3,000 /uL 11. Uncontrolled neurological and psychological disorders 12. Hypersensitivity of contrast agent 13. Uncontrolled hypertension (maximum pressure >185 mmHg or minimum pressure > 110 mmHg) 14. One of below conditions in CT scan Midline sift Low density area more than one third Intracranial hemorrhage AVM Aneurysm Complete occlusion of carotid artery 15. Stenosis of arteries to be impossible for laser induced thrombolysis 16. Previous injury of artery 17. Within 90 day of alive 18. Treatment with any investigational compound within 12 weeks before IC 19. Blood sugar =< 50 mg/dL or > 400 mg/dL 20. Seizure 21. Failure of reopening by previous thrombectomy 22. Any serious medical or psychiatric illness that could, in the opinion of the investigator, potentially interfere with the completion of treatment according to this protocol. 23. Cerebral hemorrhage after t-PA treatment in CT scan 24.Leakage of the contrast agent before laser treatment

发起方

Hamamatsu univeristy hospital