CTRI/2022/02/040276
Completed
未知
A study to evaluate the effect of Alpha lipoic acid on inhibition of platelet aggregation in diabetic neuropathy patients on Gabapentin or Pregabalin
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Indian council of Medical Research
- Enrollment
- 52
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\.Type 2 diabetic patients of either sex aged between 30 \- 65 years
- •2\.Duration of diabetes \>10 ± 5 years
- •3\.Symptomatic diabetic polyneuropathy patients with VPT value more than 15V
- •4\.HbA1c \< 10%
- •5\.Patients on stable dose of antidiabetic drug or combination of Metformin \+ sulphonyl urea \+
- •DPP4 Inhibitors for the past 3 months
- •6\.Patients on stable dose of Gabapentin 300 mg BD or Pregabalin 75mg BD for past 3 months
- •7\.Serum creatinine \< 2 mg/dl
Exclusion Criteria
- •1\.Any other conditions causing neuropathic pain
- •2\.History of hypersensitivity to alpha Lipoic acid
- •3\.Patients on antiplatelet drugs
- •4\.Patients receiving other antioxidants
- •5\.Patients with active cardiovascular disease
- •6\.Patients with liver dysfunction (ALT / AST \> 3 times the upper limit of normal)
- •7\.Patients with clinically significant skin disease
- •8\.Pregnant and lactating women.
Outcomes
Primary Outcomes
Not specified
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