Mapping Sex-by-genotype Interactions in Brain Functions: Connectivity between Polymorphisms of Dopamine Related Genes and Sexual Dimorphism in Cognitive Flexibility and Inhibitio
- Conditions
- Standard MRI and DTI examination without direct medical applicationsThis research utilizes brain imaging techniques with healthy participants onlywithout any medical applications
- Registration Number
- NL-OMON47945
- Lead Sponsor
- niversiteit Leiden
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 160
Participants, males and females, will be the ones with successful genotyping of
COMT and DRD2, with normal or corrected to normal vision, aged between 18 and
30. Their age would not exceed thirty as the direction of genotype influence
may change due to age increase (Gajewski et al., 2011).
Potential participants will be pre-screened for contraindications for fMRI,
which include metal implants, heart arrhythmia, claustrophobia, and possible
pregnancy (in females). They will additionally be pre-screened for head trauma,
history of neurological or psychiatric illness and/or use of psychotropic
medications. The ones with the positive results in pre-screen section will be
excluded. In addition, any potential participant that uses marijuana, alcohol
and recreational drug will be excluded.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method