Effect of varicocele correction surgery on the quality of sperm
Not Applicable
Recruiting
- Conditions
- VaricoceleC12.294.936
- Registration Number
- RBR-5zy6vw
- Lead Sponsor
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Male
- Target Recruitment
- Not specified
Inclusion Criteria
Men with varicocele in grades II and III; aged between 18 and 45; not having undergone previous varicocelectomy.
Exclusion Criteria
Smoking; excessive use of alcohol; drug abuse; genetic damage; prior varicocele correction surgery; testicular trauma; urogenital infections suspicion; cancer; endocrinopathies; treatments that may influence the testicular functions.
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Difference in sperm DNA fragmentation rate, semen quality and hormonal parameters in men with varicocele who underwent or not to varicocelectomy, verified by comparative analysis before and after nine months of intervention. For the evaluation of outcomes will be used Halosperm G2® kit for the analysis of sperm DNA fragmentation rate, spermogram following the normal range indicated by the World Health Organization (2010) to assess the seminal quality, and serum levels of hormones FHS, LH, prolactin, SHBG and FAI for hormonal evaluation. A determination of whether there are differences between the parameters evaluated before and after nine months will be made, and from statistical analysis between groups, the changes are considered significant to achieve p <0.05.
- Secondary Outcome Measures
Name Time Method Secondary outcomes are not expected.