Memantine versus Valproate in episodic migraine
- Conditions
- Migraine without aura.Migraine without aura [common migraine]
- Registration Number
- IRCT2013112611424N2
- Lead Sponsor
- Vice Chancellor for research of Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Men and women diagnosed with migraine within an age range of 18-65 and the onset of disease before their 50s; The duration of migraine is at least 1 year; at least 6 attacks per month; at least 48 hours without headache between 2 attacks; no migraine prophylaxis until inclusion
Exclusion criteria:Renal dysfunction; Having ICDH-II criteria for medication overuse headache; Taking antipsychotics or antidepressants in last 3 months; Drug or alcohol abuse; Allergic reactions to memantine and Its compounds; Resistance to all acute migraine medications; Pain disorders; severe psychiatric disorder; Severe infections; Malignancy; Low chance of survival; Severe cardiac and vascular diseases; Neurodegenerative diseases; Pregnancy and lactation; Women in childbearing age and sexually active are included in the study, only if they receive contraception; MIDAS greater than 18
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The average number of attacks in each month. Timepoint: 3 months of retrospective history taking before intervention, 1 month of prospective history taking before intervention, 3 months after onset of intervention. Method of measurement: Migraine diary.
- Secondary Outcome Measures
Name Time Method