NCT02795351已完成早期 1 期
The Effect of the Selective PDE5 Inhibitor, Sildenafil, on Aura and Migraine Headache Induction.
适应症
干预措施
相关药物
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Aura and migraine like headache
研究概览
简要总结
In a double blind placebo-controlled cross-over study the effect of Sildenafil on aura and migraine headache induction is tested in patient with migraine with aura.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Migraine with aura
- •Minimum of 2 attacks/year
排除标准
- •Any other type of headache, except tension-type headache < 4 days per month
- •History of cardio- or cerebrovascular diseases
- •Hypertension or hypotension
- •Any daily intake of medication, including prophylactic migraine treatment, except oral contraceptives
- •Pregnancy and lactation
研究组 & 干预措施
Active
Experimental
Sildenafil 100 mg single dose
干预措施: Sildenafil (Drug)
Placebo
Placebo Comparator
Placebo capsule
干预措施: Placebo (Drug)
结局指标
主要结局
Aura and migraine like headache
时间窗: 14 hours
Induction of aura reported by an aura diary for 14 hours post medication
次要结局
- Markers of endothelial function in blood(2 hours)
- Migraine without aura(14 hours)
研究者
Christina Kruuse
Consultant neurologist, associate professor
Herlev Hospital
研究点 (1)
Loading locations...
相似试验
招募中
不适用
Hypersensitivity to Phosphodiesterase 5 Inhibition in Post-Traumatic HeadachePost-Traumatic HeadacheNCT05669885Danish Headache Center21
已完成
2 期
The effect of sildenafil (REVATIO®) on post cardiac surgery acute kidney injuryAcute Kidney InjuryISRCTN18386427niversity of Leicester (UK)129
已完成
早期 1 期
Induction of Migraine Aura With CilostazolStrokeMigraine With AuraNCT02253004Herlev Hospital16
终止
4 期
Effects of Oral Sildenafil on Mortality in Adults With PAHPulmonary Arterial HypertensionNCT02060487Pfizer's Upjohn has merged with Mylan to form Viatris Inc.385
已完成
4 期
Healthy Volunteer Study of Sildenafil Effects Upon VisionBlindnessNCT00251784University of Cambridge