Exercise for Fighting Oncology Repercussions After Treatment

Not Applicable

Not yet recruiting

• Conditions: Neoplasms

• Registration Number: NCT05980325
• Lead Sponsor: Universitat Pompeu Fabra

Brief Summary

Cancer survival rates are currently on the verge of 70% at 5 years since diagnosis. Recent improvements in main cancer therapies including chemotherapy, radiotherapy, surgery and immunotherapy as well as developments of new biological therapies have significantly improved survival rates but unfortunately, cancer-related side effects continue to affect many patients even years after completion of main treatments. Exercise has been shown to not only ameliorate cancer-related effects before, during and after treatment but also improve disease-free and overall survival rates by decreasing risk factors associated with cancer risk and improving resilience to treatment. In this non-randomised, three-arm study, we aim to assess the effects of three forms of exercise (i.e: Nordic Walking, Aquatic Exercise and Functional Exercise) on physical performance, cancer-related fatigue, health-related quality of life and cancer-specific symptoms in a wide range of cancer survivors.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-07-28
• Study First Submitted QC: 2023-07-28
• Study First Posted: 2023-08-08
• Status Verified: 2024-12
• Last Update Submitted: 2024-12-03
• Last Update Posted: 2024-12-06
• Study Start: 2025-01-08
• Primary Completion: 2026-01-01
• Study Completion: 2026-07-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

• Adults diagnosed with cancer
• Completion of any cancer therapy in the previous 3 months with the exception of hormonal therapy
• Patients living within the Maresme Area
• No contraindications for exercise (oncology clearance or Physical Activity Readiness Questionnaire negative)

Exclusion Criteria

• Patients with any neurologic, cognitive or musculoskeletal impairments that prevent them to engage in any assessment test or exercise modality.
• Patients with unstable cardiac, respiratory or metabolic diseases
• Unable to speak or read Catalan or Spanish

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Health-Related Quality of Life	12 weeks from baseline	HRQoL measured with the EORTC Quality of Life C30 questionnaire

Secondary Outcome Measures

Name	Time	Method
Estimated one-repetition maximum	12 weeks from baseline	Estimated maximal muscle strength using a linear Encoder for two main muscle groups: i) chest and ii) quads
Lower limb muscle endurance	12 weeks from baseline	Lower limb muscle endurance measured as the maximum number of sit-to-stand repetitions performed in 30 seconds
Functional capacity	12 weeks from baseline	Walking distance covered during a self-pace 6 minute walk test
Cancer-related fatigue	12 weeks from baseline	Cancer-related fatigue as measure with the Brief Fatigue Inventory
Cardiorespiratory fitness	12 weeks from baseline	A steady state cardiopulmonary exercise testing with breath-by-breath analysis and lactate measurement to determine submaximal cardiorespiratory fitness