Preclinical Cardiomyopathy in Type 1 Diabetes: Correlation With Autonomic Dysfunction
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Diabetes Mellitus, Type 1
- Sponsor
- Roberto Léo da Silva
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Left ventricular hypertrophy
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Type 1 diabetes mellitus is a chronic autoimmune disease, associated with an increased risk of cardiovascular diseases. The development of cardiomyopathy in type 1 diabetes, independent of hypertension and coronary heart disease, is still controversial. A possible mechanism for diabetic cardiomyopathy is autonomic dysfunction. This study aims to evaluate cardiac function and structure, and to relate them with autonomic dysfunction in type 1 diabetes.
Investigators
Roberto Léo da Silva
Clinical Director
Instituto de Cardiologia de Santa Catarina
Eligibility Criteria
Inclusion Criteria
- •type 1 diabetes mellitus
Exclusion Criteria
- •hypertension
- •coronary artery disease
- •heart valve disease
- •ventricular dysfunction
- •radiotherapy or chemotherapy
- •alcoholism
- •limited acoustic window
Outcomes
Primary Outcomes
Left ventricular hypertrophy
Time Frame: At patient inclusion.
Incidence of patients with LV mass by linear measurements \> 95 g/m2 if women and \> 115 g/m2 if men.
Left ventricular diastolic dysfunction
Time Frame: At patient inclusion.
Incidence of patients with signs of diastolic dysfunction: average E/e' ratio (abnormal when \> 14)
Left atrial dysfunction
Time Frame: At patient inclusion.
Incidence of patients with abnormal reservoir strain (normal range: 38%-41%), or abnormal conduit strain (normal range: 21%-25%), or abnormal contractile strain (normal range: 16%-19%).
Preclinical myocardial dysfunction
Time Frame: At patient inclusion.
Incidence of patients with alteration in left ventricular myocardial strain (≤ 17% in absolute value).