Differences in levels of heart fat in people living with HIV and the general populatio

Not Applicable

• Conditions: Epicardial adipose tissue (EAT) volume and cardiovascular (CVD) risk in people living with HIV and general populations; Circulatory System

• Registration Number: ISRCTN47550369
• Lead Sponsor: niversity of Liverpool

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2024-02-16
• Last Update Posted: 27 February 2024
• Study Completion: 2025-03-01

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1. >40 years old
2. HIV-positive
3. Stable ART for >6 months with two VL <40 copies/ml based on local testing protocols
4. CD4 count >200cells/mm3 for >2 years from recruitment
5. Understand the study procedures, be able to comply with study procedures and voluntarily agree to participate by giving informed written consent

Exclusion Criteria

1. Subjects unable to comply with the study protocol
2. History of severe renal impairment (eGFR <30ml/min)
3. History of severe hepatic impairment (Child-Pugh Score >9)
4. Active hepatitis B or hepatitis C
5. Any active illness, which in the opinion of the investigator precludes participation in the study
6. History of cancer
7. Active illicit intravenous drug use
8. Investigators may decide the subject cannot proceed if there are any relevant other abnormal results in screening assessments
9. History or current GLP-1 agonist use
10. For female subjects: pregnancy or breastfeeding at screening.
11. Subjects currently taking: Atypical antipsychotics, omega 3 supplements, Telmisartan/Irbesartan, Thiazolidinediones or regular NSAID use
12. Familial hypercholesterolaemia

Study & Design

• Study Type: Observational
• Study Design: Not specified