Preemptive Analgesia for Primary Dysmenorrhoea: a Randomized Controlled Trial
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 84
- 试验地点
- 1
- 主要终点
- change in the Degree of pain
研究概览
简要总结
Preemptive analgesia before the release of pain mediators
详细描述
spasmodic dysmenorrhea is one of the most distressing symptoms in women. adolescents shows a usual absence from school . prostaglandin release is one of the most accepted theory responsible for spasmodic dysmenorrhea.
Non steroidal anti inflammatory Drugs were proved to be one of the alternative medications for spasmodic dysmenorrhea.
Getting the idea of what is called preemptive anesthesia by blocking the receptors before catching pain mediators the study participants will be divided randomly into 2 group group 1 receiving ttt 2 days before the anticipated menstruation and group 2 receiving ttt only during menstruation as analgesia
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 15 Years 至 25 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •nulliparous ladies
- •with regular menstrual cycle pattern
- •those experienced history of dysmenorrhea (primary or spasmodic)
- •patients able to sallow tables
排除标准
- •irregular cycles
- •any associated local causes( pelvic infection, endometriosis, fibroid or others)
- •patients with familial Mediterranean fever or other intermenstrual attacks of abdominal pain
- •gastric or duodenal ulcers or gastritis
- •other contraindications to non steroidal anti-inflammatory drugs
- •patients with severe diminution of vision or color discrimination
- •patients with any depressive or mood disorders
- •patients receiving any hormonal treatment
研究组 & 干预措施
premenstruation group
preemptive mefenamic acid 500mg tablets every 8 hours starting 2 days before anticipated menstruation and during the first 2 days of the cycle
干预措施: preemptive mefenamic acid (Drug)
menstruation group
mefenamic acid 500mg tablets every 8 hours during the first 2 days of the cycle
干预措施: mefenamic acid (Drug)
结局指标
主要结局
change in the Degree of pain
时间窗: 4 months
severity of pain according to visual pain analog scale
次要结局
未报告次要终点
研究者
Hanan Nabil
Associate Professor Obstetrics and Gynecology
Mansoura University