rTMS in Facilitation of Working Memory in PD

Not Applicable

• Conditions: Parkinson Disease
• Interventions: Device: rTMS; Behavioral: Cognitive training program

• Registration Number: NCT03059212
• Lead Sponsor: Taipei Veterans General Hospital, Taiwan

Brief Summary

Ten sessions of repetitive transcranial magnetic stimulation yield ability to upregulate the function of primary motor cortex and prefrontal cortex that play key roles in motor and frontal memory processing.

Detailed Description

Excitatory (\>3Hz) rTMS could facilitate the brain cortex and neuroplasticity that benefits motor control and working memory when the coil is applied over primary motor cortex or dorsolateral prefrontal cortex.

Study Timeline

• Study First Submitted: 2017-01-16
• Study First Submitted QC: 2017-02-16
• Study First Posted: 2017-02-23
• Study Start: 2017-10-30
• Status Verified: 2021-01
• Last Update Submitted: 2021-01-05
• Last Update Posted: 2021-01-08
• Primary Completion: 2021-12
• Study Completion: 2021-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Clinical diagnosis of Parkinson's Disease
• With symptoms of cognitive impairments, such as memory, attention, or language decline.

Exclusion Criteria

• History of seizure attack
• Alzheimer's disease
• With cardiac pacemaker implantation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Sham rTMS	rTMS	Sham rTMS, one session per day, for 10 days
High frequency rTMS with cognitive training	Cognitive training program	Real rTMS and cognitive training, one session per day, for 10 days
High frequency rTMS	rTMS	Real rTMS, one session per day, for 10 days
High frequency rTMS with cognitive training	rTMS	Real rTMS and cognitive training, one session per day, for 10 days

Primary Outcome Measures

Name	Time	Method
Change of Repeatable Battery for the Assessment of Neuropsychological Status	up to 12 weeks	This battery measures the cognitive functions including attention, memory, language, visuospatial domains.

Secondary Outcome Measures

Name	Time	Method
Change of Montreal Cognitive Assessment ; MoCA	up to 12 weeks	Assessing cognitive function including delaying recall, attention, executive function, language...

Trial Locations

Locations (1)

Taipei Veteran General Hospital; 🇨🇳 Taipei, Taiwan