Clinical profile (details related to disease, treatment and response)of children who received High Frequency mode of ventilation for respiratory failure due to inadequate oxygen levels in post-OSCAR and OSCILLATE trials era

Not yet recruiting

• Conditions: Acute and chronic respiratory failure,

• Registration Number: CTRI/2020/12/029648
• Lead Sponsor: DR ANUPAMA YERRA

Brief Summary

THIS IS A SINGLE CENTRE, OBSERVATIONAL, STUDY WITH  RETROSPECTIVE STUDY PERIOD OF 3 TEAR DURATION ( SINCE JANUARY 2017) AND PROSPECTIVE STUDY OF 1 YEAR PERIOD WHICH AIMS TO STUDY THE CLINICAL PROFILES OF CHILDREN BETWEEN AGES 1 MONTH AND 18 YEARS WITH HYPOXEMIC RESPIRATORY FAILURE WHO RECEIVED HIGH-FREQUENCY VENTILATION WITH SECONDARY OBJECTIVES OF STUDYING THE ASSOCIATION OF HFOV SETTINGS ON MORTALITY, VENTILATION DAYS, PICU STAY, AIR LEAKS, HEMODYNAMIC INSTABILITY, TO INVESTIGATE POSSIBLE OUTCOME PREDICTORS FOR CHILDREN ON HFOV, TO STUDY ASSOCIATION OF CUMULATIVE FLUID BALANCE, RENAL ANGINAL INDEX, AND PRONING MANEUVERS ON THE OUTCOME OF CHILDREN ON HFOV. RETROSPECTIVE DATA OF LAST 3 YEARS (SINCE JANUARY 2017 WILL ALSO BE COLLECTED)

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2020-07-12
• Study Start: 2020-10-12

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

All children aged between 1 month and 18 years with hypoxemic respiratory failure requiring high frequency oscillation ventilation.

Exclusion Criteria

Not provided

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the clinical profile of children with hypoxemic respiratory failure who survived on high frequency ventilation with children with hypoxemic respiratory failure who died on high frequency ventilation	1 year

Secondary Outcome Measures

Name	Time	Method
association of cumulative fluid balance, renal angina index on outcome of children on HFOV	1 year
association of HFOV settings on outcome parameters like ventilator days, air leaks, hemodynamic instability, PICU stay, mortality	1 year
possible outcome predictors for children with hypoxemic respiratory failure on HFOV	1 year
association of proning maneuvers on the outcome of children on HFOV	1 year

Trial Locations

Locations (1)

RAINBOW CHILDRENS HOSPITAL; 🇮🇳 Hyderabad, TELANGANA, India

RAINBOW CHILDRENS HOSPITAL

🇮🇳Hyderabad, TELANGANA, India

DR ANUPAMA YERRA

Principal investigator

8008740697

puttaanu@gmail.com