A Follow-up Colonoscopy Examination in Patients Who Had Previously Undergone Screening Colonoscopy

Completed

• Conditions: Colonic Cancer
• Interventions: Procedure: colonoscopy

• Registration Number: NCT00280332
• Lead Sponsor: Chinese University of Hong Kong

Brief Summary

* To determine the prevalence of colonic neoplasm in patients who had previously undergone screening colonoscopy

* To determine the optimal time interval for re-screening in average risk individuals

* To determine potential baseline characteristics that predicts adenoma recurrence

Detailed Description

Colorectal cancer (CRC) is the second commonest cancer in Hong Kong, and tends to be increasing. Screening for colorectal cancer can reduce the cancer incidence and mortality by detecting early lesions. However, the best interval for a follow up colonoscopy, particularly for those with normal baseline colonoscopy, remains largely unknown.

This study aim to determine the prevalence of colonic neoplasm in average-risk patients who had previously undergone screening colonoscopy and the optimal time interval for re-screening.

Study Timeline

• Study First Submitted: 2006-01-20
• Study First Submitted QC: 2006-01-20
• Study First Posted: 2006-01-23
• Study Start: 2006-03
• Primary Completion: 2007-11
• Study Completion: 2007-11
• Status Verified: 2008-05
• Last Update Submitted: 2008-05-09
• Last Update Posted: 2008-05-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 560

Inclusion Criteria

• Subjects who are previously participated in one of our two screening colonoscopy studies [Sung, Gastroenterol 2003; Leung, AJG 2004]
• Asymptomatic on first screening colonoscopy
• Age>50and <75
• No family history of CRC
• No other colonoscopy except the baseline screening colonoscopy

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Exclusion Criteria

• Subjects who refused consent
• Subjects who are not warrant follow up colonoscopy

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
A	colonoscopy	colonic adenoma
B	colonoscopy	colonic without adenoma

Primary Outcome Measures

Name	Time	Method
The prevalence of advanced colonic adenoma in the re-screening population	5 year from index colonoscopy

Secondary Outcome Measures

Name	Time	Method
The time to adenoma adenoma development according to different baseline characteristics of patients and colonoscopy findings	5 years from index colonoscopy

Trial Locations

Locations (1)

Endoscopy Center, Prince of Wales Hospital; 🇨🇳 Hong Kong (SAR), China