Muscle Evaluation of Patients Infected by the Coronavirus Requiring Mechanical Ventilation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- SARS-CoV-2 Acute Respiratory Disease
- Sponsor
- Hospital Israelita Albert Einstein
- Enrollment
- 138
- Locations
- 1
- Primary Endpoint
- Muscle thickness
- Last Updated
- 4 years ago
Overview
Brief Summary
Patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents risk to develop muscle weakness associated with prolonged period of mechanical ventilation support and hospital stay.
Detailed Description
Intensive care unit (ICU) acquired muscle weakness affects both respiratory and peripheral muscles and can contribute to worsen clinical and functional outcomes. In this way, ultrasonography muscle evaluation could help to identify early alterations guiding the therapeutic planning and allowing to monitor the interventions performed. Therefore, the investigators intend to follow up mechanically ventilated patients with confirmed diagnosis of COVID-19 during ICU stay to quantify the diaphragm, parasternal intercostal, abdominals and femoral quadriceps muscles thickness assessed by ultrasonography. Additionally, functional capacity, frailty and level of physical activity will be evaluated and followed for pre-admission condition and 30, 90 and 180 days after hospital discharge .
Investigators
Eligibility Criteria
Inclusion Criteria
- •patients admitted to ICU
- •having a confirmed diagnosis of COVID-19
- •requiring invasive mechanical ventilation.
Exclusion Criteria
- •exclusive palliative care;
- •neuromuscular diseases;
- •patients who evolve with the need for lower limb amputation;
- •previous known diaphragm malformations and dysfunctions;
- •patients transferred from other institutions under invasive mechanical ventilation;
- •clinical conditions that make the respiratory and peripheral muscle assessment through ultrasound unfeasible.
Outcomes
Primary Outcomes
Muscle thickness
Time Frame: Day 1, 5, and within 24 hours after ICU discharge.
Change in the thickness of the diaphragm and quadriceps femoris muscles.
Secondary Outcomes
- Respiratory muscle thickness(At the end of data collection, within 24 hours after ICU discharge.)
- Muscle thickness and functional outcomes(At the end of data collection, within 24 hours after ICU discharge.)
- Grip strength and clinical outcomes(At the end of data collection, within 24 hours after ICU discharge.)
- Mobility level correlation with clinical and functional outcomes(At the end of data collection, within 24 hours after ICU discharge.)