Effect of Tranexamic acid on peri operative blood loss in Primary Total Knee Replacement
试验速览
- 阶段
- 2/3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- At the end of study their might be less blood loss in patient manage with intravenous tranexamic acid compare to patient manage with peri articular infiltration of tranexamic acid in posterior aspect of capsule.
研究概览
简要总结
ABSTRACT
Tranexamic acid is an Anti-fibrinolytic agent. It is used to treat or prevent excessive blood loss from major trauma, major surgeries like Total knee replacement, Total hip replacement. Intravenous or topical administration of tranexamic acid seems to be an effective method in preventing blood loss and blood transfusions following TKR.as compared to infiltration of tranexamic acid in posterior aspect of whole capsule. Aim of this study to investigate the effect of tranexamic acid to control blood loss during surgery and post operative. In this study we propose to evaluate the use of tranexamic acid in reducing bleeding, need for transfusion of blood and blood products, and prevalence of deep vein thrombosis in primary TKR. Attention was paid to early complication potentially associated with TXA administration hematoma, wound exudate, or knee swelling.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- None
入排标准
- 年龄范围
- 40.00 Year(s) 至 80.00 Year(s)（—）
- 性别
- All
入选标准
- •Patient undergoing primary Total knee replacement due to osteoarthritis or rheumatoid arthritis.
排除标准
- •Allergies to drugs used 2)Changes related to coagulation profile 3)Use of Antiplatelet drugs seven days before surgery 4)Kidney or Liver disease 5)Previous history of deep venous thrombosis or pulmonary embolism.
结局指标
主要结局
At the end of study their might be less blood loss in patient manage with intravenous tranexamic acid compare to patient manage with peri articular infiltration of tranexamic acid in posterior aspect of capsule.
时间窗: Assessment will be done at 12 months.
次要结局
未报告次要终点
研究者
Dr Sharad Sawant
Datta Meghe Institute of Higher Education And Research Sawangi Meghe