Anthropometric Measurements in Children Having Transfusion-dependent Beta Thalassemia.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 367
- 主要终点
- Height in transfusion-dependent β-thalassemia pediatric patients in Pakistan were recorded to assess growth rate
研究概览
简要总结
The aim of this study was to determine the anthropometric measurements in transfusion-dependent β-thalassemia children in Pakistan. The secondary aim was to correlate serum ferritin with the physical growth
详细描述
Material and methods
Setting The study was conducted at the Sections of Hematology and Clinical Chemistry in the Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan during January 2013 to December 2014. Patient recruitment was conducted at a non-profit organization named Fatimid Foundation Karachi (FFK), which provides free of cost blood components to the patients with various blood disorders. There are more than 4000 registered patients of thalassemia and hemophilia at FFK.
Patient selection After informed consent from their parents, 367 pediatric patients (age 5-17 year) with transfusion-dependent β-thalassemia were recruited. All patients were diagnosed based on hemoglobin electrophoresis or high-performance liquid chromatography.
Data collection Detail history was collected by a trained research officer on a predetermined questionnaire. The following information was collected from medical records of the patients: demographics (age, gender, age at the time of diagnosis and at first transfusion), anthropometrics (height and weight), and clinical details (blood transfusion history, iron chelation, last pre-transfusion hemoglobin, and last serum ferritin levels).
Sample collection Five milliliter of blood samples were collected in two tubes (ethylenediaminetetraacetic acid and gel) at Fatimid foundation by a trained phlebotomist prior to blood transfusion to determine hemoglobin and serum ferritin.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 5 Years 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Children with transfusion dependent beta thalassemia major
- •Age 5 to 17 years
- •Subjects with informed consent
排除标准
- •Age more than 17 years
- •Subjects who refused informed consent
结局指标
主要结局
Height in transfusion-dependent β-thalassemia pediatric patients in Pakistan were recorded to assess growth rate
时间窗: Jan 2013 to Dec 2014
Height in meters will be recorded from medical records of the patients
Weight in transfusion-dependent β-thalassemia pediatric patients in Pakistan were recorded to assess growth rate
时间窗: Jan 2013 to Dec 2014
Wight in kilograms will be recorded from medical records of the patients
Assessment of physical growth in transfusion-dependent β-thalassemia pediatric patients in Pakistan were recorded to assess growth rate
时间窗: Jan 2013 to Dec 2014
World health organization (WHO) 2007 growth charts were used for boys and girls to assess their physical growth. Body mass index (BMI) was computed as weight in kg/height in square meters (kg/m\^2). z-Score of height (h-SDS), weight (w-SDS), and BMI (BMI-SDS) were also calculated.
Serum ferritin levels and their association with z-Score of height
时间窗: Jan 2013 to Dec 2014
Correlation was assessed between height for age z-score and serum ferritin levels. Serum ferritin was measured by chemi-luminescent micro-particle immunoassay on Cobos® E-601. The association of z-Score of height with median serum ferritin levels was further confirmed by comparing these laboratory parameters in children with height z-scores \<2 with those with the z-score ≥2 using the Mann-Whitney test.
次要结局
未报告次要终点
研究者
Bushra Moiz
Professor
Aga Khan University