Factors Affecting Early Adult Lung Function
- Conditions
- Small Airway DiseaseMetabolic SyndromeEarly Adult Lung Function
- Interventions
- Diagnostic Test: Forced Oscillation Technique
- Registration Number
- NCT03187158
- Lead Sponsor
- Council of Scientific and Industrial Research, India
- Brief Summary
Attainment of peak healthy lung function during the 18-26 yr window is a strong determinant of the rate of lung function decline during the later years of life. The attainment of a healthy peak lung function is mediated by pre and peri natal exposures ( in utero environment and nutrition) and exposure to environmental toxicants and nutrition during childhood and early adulthood. Towards this Indian birth cohorts, having collected comprehensive data on maternal nutrition and anthropometry can provide invaluable insight into the factors affecting lung function growth and their effect sizes in the Indian population. Therefore, in this observational study, the Investigator will be collecting data on lung function, current nutritional and environmental exposures and linking it to pre and peri natal data of the same participants in order to understand lung function growth and the reasons for an early decline in the Indian population, using a life course approach.
- Detailed Description
Introduction:
Attainment of peak healthy lung function during the 18-26 yr window is a strong determinant of the rate of lung function decline during the later years of life. The attainment of a healthy peak lung function is mediated by pre and peri natal exposures ( in utero environment and nutrition) and exposure to environmental toxicants and nutrition during childhood and early adulthood. Towards this Indian birth cohorts, having collected comprehensive data on maternal nutrition and anthropometry can provide invaluable insight into the factors affecting lung function growth and their effect sizes in the Indian population. Therefore, in this observational study, the Investigator will be collecting data on lung function, current nutritional and environmental exposures and linking it to pre and peri natal data of the same participants in order to understand lung function growth and the reasons for an early decline in the Indian population, using a life course approach.
Sampling:
F1 generation of previously registered Indian Birth Cohorts, having collected comprehensive data on maternal exposures, nutrition and anthropometry.
Techniques Employed:
Spirometry , Forced OscillationTechnique, Anthropometry, Questionnaire, Biochemical analysis of nutritional, immunomodulatory and inflammatory biomarkers.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 500
- Men and Women
- 18-30 years
- Mothers registered in the birth cohort
- Able to perform IOS and Spirometry
- Major systemic diseases like cardiac or renal problems
- Clinically significant anemia
- Bone deformity of chest or spine
- muscular weakness
- Otherwise unable to participate in spirometry
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description New Delhi Birth Cohort Forced Oscillation Technique Study has been planned on the F1 generation of the mothers recruited under the New Delhi Birth Cohort in New Delhi, India. Data on maternal nutrition, exposures and anthropometry have been collected, in the F1 generation, the study will be adding cross sectional lung function measurement, biochemical analyses for nutritional, immunological and inflammatory biomarkers. Pune Maternal Nutrition Cohort Forced Oscillation Technique Study has been planned on the F1 generation of the mothers recruited under the PMNS study at Diabetes Unit, KEM-Pune. Data on maternal nutrition, exposures and anthropometry have been collected, in the F1 generation. This study will be adding cross sectional lung function measurement, biochemical analyses for nutritional, immunological and inflammatory biomarkers.
- Primary Outcome Measures
Name Time Method Pulmonary Function Test 12-18 months To ascertain whether healthy peak lung function values have been attained
Forced oscillation technique 12-18 months To ascertain the magnitude of airway resistance and study the prevalence of small airway disease
- Secondary Outcome Measures
Name Time Method Serum biochemistry 12-18 months To study nutritional, immunological and inflammatory biomarkers correlated with both lung function and metabolic syndrome
Trial Locations
- Locations (1)
Council of Scientific and Industrial Research-Institute of Genomics and Integrative Biology
🇮🇳New Delhi, India