Clonal Hematopoiesis of Indeterminate Potential in Venous Thromboembolism

Completed

• Conditions: Venous Thromboembolism

• Registration Number: NCT04477564
• Lead Sponsor: Centre Hospitalier Universitaire de Nīmes

Brief Summary

The aim of the study is to investigate the existence of clonal hematopoiesis of indeterminate potential (CHIP) in patients with a history of venous thromboembolism.

The study investigators make the assumption that these patients present mutations involved in CHIP occurrence.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-07-03
• Study First Submitted: 2020-07-10
• Study First Submitted QC: 2020-07-15
• Study First Posted: 2020-07-20
• Primary Completion: 2021-12-30
• Study Completion: 2022-12-30
• Status Verified: 2023-06
• Last Update Submitted: 2023-06-02
• Last Update Posted: 2023-06-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• Men and women over 50 years old who have consulted at the Hematology laboratory of the Nîmes University Hospital for the occurrence or history of venous thromboembolism
• Patient who has accepted that their DNA was kept and used in the context of research on venous thromboembolism (biobank (registration number DC-2008-290 and authorization number AC-2008-107))

Exclusion Criteria

• Patients less than 50 years old
• Patient who has refused that their DNA was kept and used in the context of research on venous thromboembolism

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
DNMT3A mutations screening	For sequencing analysis: 2 months	Next generation sequencing

Secondary Outcome Measures

Name	Time	Method
TET2, ASXL1, TP53, JAK2, SF3B1, SRSF2, GNB1, CBL, BCOR, SH2B3, PPM1D mutations screening	For sequencing analysis: 2 months	Next generation sequencing

Trial Locations

Locations (1)

CHU de Nimes; 🇫🇷 Nîmes, France