Behavioral and neuroendocrine reactivity of smokers to smoking vs non-smoking avatars in virtual reality (SMoking AvataR Trial)
- Conditions
- F17.2
- Registration Number
- DRKS00025746
- Lead Sponsor
- Zentralinstitut für Seelische Gesundheit (ZI)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Male
- Target Recruitment
- 50
Male sex, tobacco smoker.
Psychiatric comorbidity with psychiatric or psychotherapeutic treatment in the past 10 years (>1 psychiatric or psychotherapeutic treatment). Severe physical disease: cancer treatment during the past 10 years; metabolic disease (Addison's disease, Cushing's disease, hypogonadism, testosterone treatment); neurological disease (multiple sclerosis, Parkinson's disease, amyotrophic lateropathy, stroke during the past 5 years, traumatic brain disease with persistent neurological deficit); acute cardiovascular disease (first manifestation during the past 4 weeks), myocardial infarction, decompensated cardiac insufficiency; renal insufficiency; infectious disease currently being treated; rheumatological disease. Current use of medications for mental illness or use of drugs that interact with the central nervous system within a maximum of 5 half-lives. Known intolerance to high frequency flickering visual stimuli, as seen in very rare cases in certain forms of epilepsy (ascertainable through reported similar problems in past movie theater visits). Abstinence from cigarettes < 12 hours before planned study inclusion.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Explicit craving for smoking, implicit wanting of cigarette smoking (Implicit Association Test), approach behavior towards cigarette stimuli (Approach-Avoidance Test), selective attention toward cigarette stimuli (Dot-Probe Test) measured on three different occasions (smoking avatar vs non-smoking avatar; additionally: without an avatar).
- Secondary Outcome Measures
Name Time Method Oxytocin, arginine-vasopressin, cortisol, and alpha-amylase in plasma and saliva on the following test conditions: smoking avatar vs non-smokign avatar; additionally without an avatar, before and after smoking.