Phase I/II study of the combination of Oxaliplatin and S-1 in patients with advanced/recurrent colorectal cancer
Phase 1
- Conditions
- unresectable advanced/recurrent colorectal cancer
- Registration Number
- JPRN-C000000443
- Lead Sponsor
- Outpatient Oncology Unit Kyoto University Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 42
Inclusion Criteria
Not provided
Exclusion Criteria
1) during flucytosine medication 2) Active infection or inflammation 3) Uncontrolled severe Diabtes 4) patient severe medical condition 5) patient with interstitial pneumonitis or the history 6) patient with active gastrointestinal bleeding 7) patient with severe neurotoxicity 8) patient with active chicken pox 9) patient with metastasis of CNS 10) patient with other concurrent malignancy affecting on survival or adverse events 11) pregnant or nursing patient or with intent to bear baby 12) patient with allergic history to drug 13) patient with massive effusion of massive ascites 14) patient evaluated to be inadequate by a attending doctor
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Step1:safety;adverse events Step2:Disease control rate
- Secondary Outcome Measures
Name Time Method Step1:Eficacy (response rate(CR+PR),disease control rate, survival Step2: Safety, Response rate, survival