NCT00929734已完成2 期
Effect of ROsuvastatin Therapy on Peripheral Vasodilator Function, Inflammatory Markers and Pulmonary Function in Patients With StablE Chronic Obstructive Pulmonary Disease
University Hospital, Akershus1 个研究点 分布在 1 个国家目标入组 99 人开始时间: 2010年3月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 99
- 试验地点
- 1
- 主要终点
- Relative Change in Reactive Hyperemia Index (RHI)
研究概览
简要总结
The purpose of this study is to investigate whether rosuvastatin improves measures of endothelial function, decreases measures of inflammation, and improves pulmonary function in patients with stable chronic obstructive pulmonary disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Rosuvastatin
Experimental
干预措施: Rosuvastatin (Drug)
Placebo
Placebo Comparator
干预措施: Placebo (Drug)
结局指标
主要结局
Relative Change in Reactive Hyperemia Index (RHI)
时间窗: Baseline to 3 months
Endothelial function assessed with peripheral arterial tonometry, expressed as the reactive hyperemia index (RHI) as a marker for subclinical atherosclerosis and future cardiovascular risk assessment.
次要结局
- Relative Change in FEV1(Baseline to 3 months)
- Relative Change in High-sensitivity C-reactive Protein(Baseline to 3 months)
- Relative Change in Interleukin 6(Baseline to 3 months)
研究者
Torbjorn Omland
Professor of Medicine
University Hospital, Akershus
研究点 (1)
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