The Effect of Transcranial Direct Current Stimulation on Fatigue in Multiple Sclerosis

Not Applicable

Recruiting

• Conditions: G35; Multiple sclerosis

• Registration Number: DRKS00012766
• Lead Sponsor: Psychiatrische Klinik

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-07-19
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

Right handed patients
-Definite Multiple Sclerosis diagnosis according to the 2010 McDonald criteria
-Fatigue since more than 6 months as assessed by fatigue severity scale (FSS>5)
-Age between 18 and 75 years.
-Stable pharmacological and physical treatment since at least one month

Exclusion Criteria

-Relapses within the last two months
-Expanded disability status scale = 6.5
-Severe depression based on Beck Depression inventory (BDI>19)
-Daytime sleepiness based on Epworth Sleepiness Scale (ESS> 11)
-Other neurologic and psychiatric diseases

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Improvement of cognition and working memory(2-back test, Symbol Digit modalities test), and fatigue (fatigue severity scale, modified fatigue Impact scale) in the active group compared to sham group after 5 treatments.

Secondary Outcome Measures

Name	Time	Method
Improvement of mood (Hospital anxiety and Depression Scale) in the active group compared to sham group after 5 treatments. Improvement of sleep quality and mobility after active stimulation. Improvement of emotion recognition after active stimulation.