Collecting and Storing Tissue Samples From Patients With Rare or Cutaneous Non-Hodgkin Lymphoma
- Conditions
- Adult Immunoblastic LymphomaGrade 1 Follicular LymphomaMantle Cell LymphomaNon-Hodgkin LymphomaPrimary Cutaneous B-Cell Non-Hodgkin LymphomaGrade 2 Follicular LymphomaLymphoproliferative DisorderSmall Lymphocytic LymphomaChildhood Immunoblastic LymphomaMarginal Zone Lymphoma
- Interventions
- Other: Cytology Specimen Collection Procedure
- Registration Number
- NCT01000753
- Lead Sponsor
- Children's Oncology Group
- Brief Summary
This research study is collecting and storing tissue samples from patients with rare or cutaneous non-Hodgkin lymphoma. Collecting and storing samples of tissue from patients with cancer to test in the laboratory may help the study of cancer in the future.
- Detailed Description
OBJECTIVES:
I. To determine the clinical features, treatment, and outcome of patients with rare or cutaneous pediatric non-Hodgkin lymphoma (NHL).
II. To determine the pathologic and biologic features of these diseases, including molecular diagnostics and flow cytometry.
III. To establish a bank of these pathologically reviewed diseases and make specimens of blood and tissue available to qualified researchers.
IV. To determine sub-groups of these diseases that could be targeted for future biologic, pathologic, or therapeutic studies.
OUTLINE:
On study data will include presenting symptoms and signs, physical description of the tumor if it is on the skin, results of metastatic evaluation, stage (if available), blood count, markers, and the results of viral serologies. Any existing underlying conditions that could predispose to lymphoma will also be noted. Demographic and outcomes data will be stored and maintained by the COG Research Data Center. Demographic data will be linked to the specimen data in the BPC database.
The approach of this study is prospective data collection, including central pathologic review, relevant biologic studies, submission of material to the Biopathology Center (BPC) and collection of diagnostic and outcome data. Participants will be registered with a standard COG registration form for documentation of age, gender, race, date of diagnosis, initial presentation, initial work-up, and stage according to the standard staging for the specific disease, initial diagnostic procedure, and institutional diagnosis. Tissue will be sent according to guidelines in Section 4.0. Follow-up data, including relapse or progression and vital status will be reported annually for 5 years.
Patients will be followed annually for 5 years and data will be collected including vital status, evidence/absence of disease, type of treatment received, progression/relapse and whether the patient continues on study.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 174
-
Diagnosis of NHL
- Any histology, except for Burkitt or Burkitt-like, diffuse large B-cell, anaplastic large cell, or lymphoblastic lymphoma
- Primary CNS, primary cutaneous NHL, or lymphoproliferative diseases of any histology allowed
-
Pathological specimen from site not treated within the past 6 months
-
Must have specimens available
-
At least 6 months since prior chemotherapy irradiation to study lesion
-
At least 2 weeks since prior steroids
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Observational (specimen collection) Cytology Specimen Collection Procedure See Detailed Description
- Primary Outcome Measures
Name Time Method Sub-groups of these diseases that could be targeted for future biologic, pathologic, or therapeutic studies Up to 5 years Pathologic and biologic features of these diseases, including molecular diagnostics and flow cytometry Up to 5 years Establishment of a bank of these pathologically reviewed diseases and make specimens of blood and tissue available to qualified researchers Up to 5 years Clinical features, treatment, and outcomes Up to 5 years
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (130)
Children's Hospital of Philadelphia
🇺🇸Philadelphia, Pennsylvania, United States
Hospital for Sick Children
🇨🇦Toronto, Ontario, Canada
Children's Healthcare of Atlanta - Egleston
🇺🇸Atlanta, Georgia, United States
Nationwide Children's Hospital
🇺🇸Columbus, Ohio, United States
Children's Hospital of Pittsburgh of UPMC
🇺🇸Pittsburgh, Pennsylvania, United States
Rainbow Babies and Childrens Hospital
🇺🇸Cleveland, Ohio, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
🇺🇸Miami, Florida, United States
Riley Hospital for Children
🇺🇸Indianapolis, Indiana, United States
Saint Vincent Hospital and Health Care Center
🇺🇸Indianapolis, Indiana, United States
Nevada Cancer Research Foundation CCOP
🇺🇸Las Vegas, Nevada, United States
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
🇺🇸Las Vegas, Nevada, United States
University Medical Center of Southern Nevada
🇺🇸Las Vegas, Nevada, United States
Sunrise Hospital and Medical Center
🇺🇸Las Vegas, Nevada, United States
Summerlin Hospital Medical Center
🇺🇸Las Vegas, Nevada, United States
Duke University Medical Center
🇺🇸Durham, North Carolina, United States
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
🇺🇸Houston, Texas, United States
Methodist Children's Hospital of South Texas
🇺🇸San Antonio, Texas, United States
University of Texas Health Science Center at San Antonio
🇺🇸San Antonio, Texas, United States
UCSF Medical Center-Parnassus
🇺🇸San Francisco, California, United States
UCSF Medical Center-Mission Bay
🇺🇸San Francisco, California, United States
Vanderbilt University/Ingram Cancer Center
🇺🇸Nashville, Tennessee, United States
Primary Children's Hospital
🇺🇸Salt Lake City, Utah, United States
Santa Barbara Cottage Hospital
🇺🇸Santa Barbara, California, United States
Miller Children's and Women's Hospital Long Beach
🇺🇸Long Beach, California, United States
Arkansas Children's Hospital
🇺🇸Little Rock, Arkansas, United States
Alfred I duPont Hospital for Children
🇺🇸Wilmington, Delaware, United States
Eastern Maine Medical Center
🇺🇸Bangor, Maine, United States
Sinai Hospital of Baltimore
🇺🇸Baltimore, Maryland, United States
Children's Hospital and Research Center at Oakland
🇺🇸Oakland, California, United States
Connecticut Children's Medical Center
🇺🇸Hartford, Connecticut, United States
Lee Memorial Health System
🇺🇸Fort Myers, Florida, United States
Kaiser Permanente-Oakland
🇺🇸Oakland, California, United States
Lucile Packard Children's Hospital Stanford University
🇺🇸Palo Alto, California, United States
Kaiser Permanente Downey Medical Center
🇺🇸Downey, California, United States
Children's National Medical Center
🇺🇸Washington, District of Columbia, United States
Advocate Children's Hospital-Oak Lawn
🇺🇸Oak Lawn, Illinois, United States
University of Kansas Cancer Center
🇺🇸Kansas City, Kansas, United States
Children's Hospital Los Angeles
🇺🇸Los Angeles, California, United States
University of Arkansas for Medical Sciences
🇺🇸Little Rock, Arkansas, United States
Nemours Children's Clinic-Jacksonville
🇺🇸Jacksonville, Florida, United States
Golisano Children's Hospital of Southwest Florida
🇺🇸Fort Myers, Florida, United States
Saint Peter's University Hospital
🇺🇸New Brunswick, New Jersey, United States
Memorial Health University Medical Center
🇺🇸Savannah, Georgia, United States
Advocate Lutheran General Hospital
🇺🇸Park Ridge, Illinois, United States
University of Kentucky/Markey Cancer Center
🇺🇸Lexington, Kentucky, United States
Nemours Children's Clinic - Pensacola
🇺🇸Pensacola, Florida, United States
MedStar Georgetown University Hospital
🇺🇸Washington, District of Columbia, United States
Washington University School of Medicine
🇺🇸Saint Louis, Missouri, United States
Johns Hopkins All Children's Hospital
🇺🇸Saint Petersburg, Florida, United States
Advocate Children's Hospital-Park Ridge
🇺🇸Park Ridge, Illinois, United States
Blank Children's Hospital
🇺🇸Des Moines, Iowa, United States
Saint Jude Midwest Affiliate
🇺🇸Peoria, Illinois, United States
University of Iowa/Holden Comprehensive Cancer Center
🇺🇸Iowa City, Iowa, United States
University of Illinois
🇺🇸Chicago, Illinois, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone
🇺🇸New York, New York, United States
Massachusetts General Hospital Cancer Center
🇺🇸Boston, Massachusetts, United States
Roswell Park Cancer Institute
🇺🇸Buffalo, New York, United States
Saint Mary's Hospital
🇺🇸West Palm Beach, Florida, United States
Newark Beth Israel Medical Center
🇺🇸Newark, New Jersey, United States
Mission Hospital Inc-Memorial Campus
🇺🇸Asheville, North Carolina, United States
Saint Barnabas Medical Center
🇺🇸Livingston, New Jersey, United States
Dayton Children's Hospital
🇺🇸Dayton, Ohio, United States
Columbia Regional
🇺🇸Columbia, Missouri, United States
Johns Hopkins University/Sidney Kimmel Cancer Center
🇺🇸Baltimore, Maryland, United States
Hurley Medical Center
🇺🇸Flint, Michigan, United States
Michigan State University Clinical Center
🇺🇸East Lansing, Michigan, United States
Overlook Hospital
🇺🇸Summit, New Jersey, United States
Dana-Farber Cancer Institute
🇺🇸Boston, Massachusetts, United States
University of Mississippi Medical Center
🇺🇸Jackson, Mississippi, United States
Helen DeVos Children's Hospital at Spectrum Health
🇺🇸Grand Rapids, Michigan, United States
Morristown Medical Center
🇺🇸Morristown, New Jersey, United States
Dartmouth Hitchcock Medical Center
🇺🇸Lebanon, New Hampshire, United States
New York Medical College
🇺🇸Valhalla, New York, United States
Hackensack University Medical Center
🇺🇸Hackensack, New Jersey, United States
Medical City Dallas Hospital
🇺🇸Dallas, Texas, United States
Brooklyn Hospital Center
🇺🇸Brooklyn, New York, United States
Children's Hospital Medical Center of Akron
🇺🇸Akron, Ohio, United States
Novant Health Presbyterian Medical Center
🇺🇸Charlotte, North Carolina, United States
Saint Joseph's Regional Medical Center
🇺🇸Paterson, New Jersey, United States
Geisinger Medical Center
🇺🇸Danville, Pennsylvania, United States
Cleveland Clinic Foundation
🇺🇸Cleveland, Ohio, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
🇺🇸New York, New York, United States
Brooke Army Medical Center
🇺🇸Fort Sam Houston, Texas, United States
Seattle Children's Hospital
🇺🇸Seattle, Washington, United States
British Columbia Children's Hospital
🇨🇦Vancouver, British Columbia, Canada
IWK Health Centre
🇨🇦Halifax, Nova Scotia, Canada
Penn State Children's Hospital
🇺🇸Hershey, Pennsylvania, United States
East Tennessee Childrens Hospital
🇺🇸Knoxville, Tennessee, United States
State University of New York Upstate Medical University
🇺🇸Syracuse, New York, United States
Lehigh Valley Hospital - Muhlenberg
🇺🇸Bethlehem, Pennsylvania, United States
Driscoll Children's Hospital
🇺🇸Corpus Christi, Texas, United States
Children's Hospital of The King's Daughters
🇺🇸Norfolk, Virginia, United States
Childrens Oncology Group
🇺🇸Philadelphia, Pennsylvania, United States
Saskatoon Cancer Centre
🇨🇦Saskatoon, Saskatchewan, Canada
CancerCare Manitoba
🇨🇦Winnipeg, Manitoba, Canada
Prisma Health Richland Hospital
🇺🇸Columbia, South Carolina, United States
Cook Children's Medical Center
🇺🇸Fort Worth, Texas, United States
West Virginia University Charleston Division
🇺🇸Charleston, West Virginia, United States
University of Alberta Hospital
🇨🇦Edmonton, Alberta, Canada
Centre Hospitalier Universitaire Sainte-Justine
🇨🇦Montreal, Quebec, Canada
Centre Hospitalier Universitaire de Quebec
🇨🇦Quebec, Canada
Princess Margaret Hospital for Children
🇦🇺Perth, Western Australia, Australia
Providence Sacred Heart Medical Center and Children's Hospital
🇺🇸Spokane, Washington, United States
San Jorge Children's Hospital
🇵🇷San Juan, Puerto Rico
Marshfield Medical Center-Marshfield
🇺🇸Marshfield, Wisconsin, United States
McMaster Children's Hospital at Hamilton Health Sciences
🇨🇦Hamilton, Ontario, Canada
Children's Hospital of Alabama
🇺🇸Birmingham, Alabama, United States
University of Alabama at Birmingham Cancer Center
🇺🇸Birmingham, Alabama, United States
Phoenix Childrens Hospital
🇺🇸Phoenix, Arizona, United States
Wayne State University/Karmanos Cancer Institute
🇺🇸Detroit, Michigan, United States
Ascension Saint John Hospital
🇺🇸Detroit, Michigan, United States
University of Oklahoma Health Sciences Center
🇺🇸Oklahoma City, Oklahoma, United States
Children's Hospital Colorado
🇺🇸Aurora, Colorado, United States
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center
🇺🇸Denver, Colorado, United States
Tampa General Hospital
🇺🇸Tampa, Florida, United States
Saint Joseph's Hospital/Children's Hospital-Tampa
🇺🇸Tampa, Florida, United States
Walter Reed National Military Medical Center
🇺🇸Bethesda, Maryland, United States
Mayo Clinic
🇺🇸Rochester, Minnesota, United States
Children's Hospital and Medical Center of Omaha
🇺🇸Omaha, Nebraska, United States
University of Nebraska Medical Center
🇺🇸Omaha, Nebraska, United States
Legacy Emanuel Children's Hospital
🇺🇸Portland, Oregon, United States
Legacy Emanuel Hospital and Health Center
🇺🇸Portland, Oregon, United States
Children's Hospital of Wisconsin
🇺🇸Milwaukee, Wisconsin, United States
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
🇺🇸Hollywood, Florida, United States
Nemours Children's Clinic - Orlando
🇺🇸Orlando, Florida, United States
Nemours Children's Hospital
🇺🇸Orlando, Florida, United States
Children's Mercy Hospitals and Clinics
🇺🇸Kansas City, Missouri, United States
Ochsner Medical Center Jefferson
🇺🇸New Orleans, Louisiana, United States
Dell Children's Medical Center of Central Texas
🇺🇸Austin, Texas, United States
Montefiore Medical Center - Moses Campus
🇺🇸Bronx, New York, United States