Comparison of Plasma Neutrophil Gelatinase - Associated Lipocalin (NGAL) Levels

Completed

• Conditions: Prostatectomy
• Interventions: Procedure: NGAL

• Registration Number: NCT03607279
• Lead Sponsor: Antalya Training and Research Hospital

Brief Summary

The purpose of the study is to compare the effect of two surgical techniques (open vs robotic assisted) on plasma levels of NGAL (neutrophil gelatinase-associated lipocalin) after radical prostatectomy.

Detailed Description

Patients undergoing radical prostatectomy are at increased risk of acute kidney injury (AKI) because of intraoperative bleeding, obstructive uropathy and older age. In particular robot-assisted laparoscopic radical prostatectomy (RALP) which is in increasing demand as an alternative surgical option for retropubic radical prostatectomy (RRP) is associated with postoperative renal dysfunction because pneumoperitoneum during RALP can decrease cardiac output and renal perfusion. NGAL may become important for diagnosis of postoperative AKI after urogenital oncosurgery.

Study Timeline

• Study Start: 2017-01
• Primary Completion: 2017-06
• Study Completion: 2017-08
• Study First Submitted: 2018-07-23
• Study First Submitted QC: 2018-07-30
• Study First Posted: 2018-07-31
• Status Verified: 2018-12
• Last Update Submitted: 2018-12-18
• Last Update Posted: 2018-12-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 66

Inclusion Criteria

• patients who undergo prostatectomy
• American Society of Anesthesiology (ASA) I-III

Exclusion Criteria

• preexisting renal disease
• emergency surgery
• heart failure
• peripheral vascular disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
NGAL - retropubic radical prostatectomy	NGAL	Plasma NGAL was determined at baseline, 6 and 12 hrs after induction of anaesthesia
NGAL - robotic radical prostatectomy	NGAL	Plasma NGAL was determined at baseline, 6 and 12 hrs after induction of anaesthesia

Primary Outcome Measures

Name	Time	Method
Plasma NGAL	0 hours, 6 hours and 12 hours after surgery	Plasma NGAL was determined at baseline, 6 hours and 12 hours after surgery, ng/ml

Trial Locations

Locations (1)

Antalya Training and Research Hospital, Department of Anesthesiology and Reanimation; 🇹🇷 Antalya, Turkey