Comparison of Plasma Neutrophil Gelatinase - Associated Lipocalin (NGAL) Levels After Robot-assisted Laparoscopic Versus Retropubic Radical Prostatectomy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- Plasma NGAL
研究概览
简要总结
The purpose of the study is to compare the effect of two surgical techniques (open vs robotic assisted) on plasma levels of NGAL (neutrophil gelatinase-associated lipocalin) after radical prostatectomy.
详细描述
Patients undergoing radical prostatectomy are at increased risk of acute kidney injury (AKI) because of intraoperative bleeding, obstructive uropathy and older age. In particular robot-assisted laparoscopic radical prostatectomy (RALP) which is in increasing demand as an alternative surgical option for retropubic radical prostatectomy (RRP) is associated with postoperative renal dysfunction because pneumoperitoneum during RALP can decrease cardiac output and renal perfusion. NGAL may become important for diagnosis of postoperative AKI after urogenital oncosurgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •patients who undergo prostatectomy
- •American Society of Anesthesiology (ASA) I-III
排除标准
- •preexisting renal disease
- •emergency surgery
- •heart failure
- •peripheral vascular disease
结局指标
主要结局
Plasma NGAL
时间窗: 0 hours, 6 hours and 12 hours after surgery
Plasma NGAL was determined at baseline, 6 hours and 12 hours after surgery, ng/ml
次要结局
未报告次要终点
研究者
Arzu Karaveli
Study director
Antalya Training and Research Hospital