ext generation phenotyping in essential tremor

Recruiting

Conditions: essential tremor
tremor
10028037

Registration Number: NL-OMON49466

Lead Sponsor: niversitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 100

Inclusion Criteria

- For the index patient: diagnosis of essential tremor syndrome by neurologist,
in line with the consensus statement put forward by the Tremor Investigation
Group of the Movement Disorders Society and a minimum age of 18 years.
- For the family: a minimum of 3 affected relatives, belonging to a minimum of
2 generations, willing to participate.

Exclusion Criteria

- Part A, if the patient has a silver allergy
- Part A, if the patient has a pacemaker
- Part B, if the patients alcohol history is indicative of (previous) alcohol
abuse
- Part B, if the patient is pregnant or breastfeeding
- Part B, if the patient uses medication which is contraindicated in
combination with alcohol

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>In this study we will try to identify a familial phenotype of essential tremor<br /><br>in our population, based on clusters of the discovered familial features. Based<br /><br>on our recently published review (4) we will address the following features of<br /><br>interest: age at onset, cranial tremor, dystonia, alcohol responsivity and<br /><br>tremor frequency.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Features of secondary interest are:<br /><br>- Disease progression<br /><br>- Cerebellar signs (intention tremor via finger-to-nose manoeuvres, via<br /><br>finger-to-finger manoeuvres, tandem gait difficulty)<br /><br>- Parkinsonism (bradykinesia, rigidity)<br /><br>- Tremor severity (Fahn-Tolosa-Marin Essential Tremor Rating Scale part A and<br /><br>B, visual analogue scale)<br /><br>- Neurophysiological features (frequency variability, coherence analysis)<br /><br>- Discrepancies between self-reported and test-based alcohol responsivity</p><br>