The Relationship Between the Flow of Arteriovenous Fistula and Cardiac Function in Haemodialysis Patients

Completed

• Conditions: Complication of Hemodialysis

• Registration Number: NCT02747966
• Lead Sponsor: Sun Yat-sen University

Brief Summary

A prospective longitudinal surveillance for a period of 2 months. Sample - identify suitable Chronic Kidney Disease (CKD) patients who undergo HD with functioning AVF. Participants at various age range and both sexes are recruited to observe their access flow, access recirculation and cardiac function and assess their relationship.

Detailed Description

All patients recruited who met the inclusion criteria were investigated access flow, access recirculation and cardiac function(including cardiac output,cardiac index,central blood volume,et al).Measurement time is the beginning of HD session (first 30min to 1 hr),Middle of HD session (optional),and the end of the HD session (1hr to 30 min prior to end of session). The follow-up duration is 6 months and 12 months.Repeat the assessment at the above time points.

Study Timeline

• Study Start: 2009-04
• Primary Completion: 2012-04
• Study Completion: 2012-04
• Study First Submitted: 2015-05-21
• Status Verified: 2016-04
• Study First Submitted QC: 2016-04-21
• Study First Posted: 2016-04-22
• Last Update Submitted: 2016-04-25
• Last Update Posted: 2016-04-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Patients undergo HD with native AVF
• AF of AVF between 300ml/min and 1800ml/min

Exclusion Criteria

• Patients whose AVF developed Access Recirculation (AR) which cannot be resolved at the time of measurement
• Patients developed access or systemic infection during the study period

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
to access the chang of the fistula blood flow in HD patients using Ultrasound Dilution method	Change of the fistula blood flow from baseline to 6 months

Secondary Outcome Measures

Name	Time	Method
Changes of the Oxygen delivery ( Adequacy of hemoglobin level to Epoetin) during the course of hemodialysis therapy	from baseline to 6 months
Changes of the Cardiac Index (CI) during the course of hemodialysis therapy	from baseline to 6 months

Trial Locations

Locations (1)

The 1st Affiliated Hospital, Sun Yet-sen University; 🇨🇳 Guangzhou, Guangdong, China