Effects of IV Tranexamic Acid on the Thromboelastogram in Patients Undergoing Total Hip or Knee Arthroplasty
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- West Virginia University
- Enrollment
- 60
- Primary Endpoint
- All time measurements which indicate various aspects of clotting cascade
Study Overview
Brief Summary
Blood management is an important part of successful total joint replacement. Loss of blood and transfusion can lead to poor outcomes for patients. The use of tranexamic acid (TXA) has become a standard component to many blood management programs. It is used to treat or prevent excessive blood loss during surgery and in various medical conditions such as excessive bleeding or hemorrhage. A normal body process prevents blood clots that occur naturally from growing and causing problems. When this process becomes overactive it can result in excessive bleeding, leading to increased blood transfusions. The proposed study seeks to evaluate the relationship between TXA and thromboelastogram (TEG) results.
Study Design
- Study Type
- Observational
- Observational Model
- Case Only
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 40 Years to 90 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Primary total hip and knee arthroplasty patients presenting to WVU Center for Joint Replacement
- •40-90 years old
Exclusion Criteria
- •Known coagulopathy
- •History of venothrombotic event
- •Unstable angina
- •Recent Myocardial infarction (MI)
- •History of bleeding events
- •History of chronic anemia
- •Preoperative anemia
- •Current use of blood thinners including aspirin
Outcomes
Primary Outcomes
All time measurements which indicate various aspects of clotting cascade
Time Frame: 3 months
Data derived from the TEG which includes R, MA, LY30 (R = clotting factors, MA clot strength and platelet function and LY30 is fibrinolysis).
Secondary Outcomes
- Blood loss and transfusions(3 months)
Investigators
Matthew Dietz, MD
Assistant Professor
West Virginia University