Risk Reduction in Coronary Heart Disease

Not Applicable

Completed

• Conditions: Coronary Heart Disease
• Interventions: Behavioral: smoking cessation; Drug: betablocker, diuretics, ACEI, ARB,; Drug: statins, ezetimibe; Behavioral: training; Biological: influenza vaccine; Drug: metformin, glimepiride, insulin; Behavioral: weight reduction

• Registration Number: NCT00679237
• Lead Sponsor: Sorlandet Hospital HF

Brief Summary

Study hypothesis: Multifactorial risk reduction in coronary heart disease can reduce the risk of new coronary heart disease and death

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2007-07-05
• Study Start: 2007-09
• Study First Submitted QC: 2008-05-14
• Study First Posted: 2008-05-16
• Primary Completion: 2019-12
• Study Completion: 2019-12
• Status Verified: 2021-03
• Last Update Submitted: 2021-03-16
• Last Update Posted: 2021-03-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1600

Inclusion Criteria

• acute myocardial infarction, CABG or PCI

Exclusion Criteria

• Age < 18 and age > 80
• pregnant
• critical illness
• drug abuse

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Multifactorial intervention	smoking cessation	Smoking cessation betablocker, diuretics, ACEI, ARB, statins, ezetimibe training influenza vaccine weight reduction metformin, glimepiride, insulin
Multifactorial intervention	betablocker, diuretics, ACEI, ARB,	Smoking cessation betablocker, diuretics, ACEI, ARB, statins, ezetimibe training influenza vaccine weight reduction metformin, glimepiride, insulin
Multifactorial intervention	statins, ezetimibe	Smoking cessation betablocker, diuretics, ACEI, ARB, statins, ezetimibe training influenza vaccine weight reduction metformin, glimepiride, insulin
Multifactorial intervention	training	Smoking cessation betablocker, diuretics, ACEI, ARB, statins, ezetimibe training influenza vaccine weight reduction metformin, glimepiride, insulin
Multifactorial intervention	influenza vaccine	Smoking cessation betablocker, diuretics, ACEI, ARB, statins, ezetimibe training influenza vaccine weight reduction metformin, glimepiride, insulin
Multifactorial intervention	metformin, glimepiride, insulin	Smoking cessation betablocker, diuretics, ACEI, ARB, statins, ezetimibe training influenza vaccine weight reduction metformin, glimepiride, insulin
Multifactorial intervention	weight reduction	Smoking cessation betablocker, diuretics, ACEI, ARB, statins, ezetimibe training influenza vaccine weight reduction metformin, glimepiride, insulin

Primary Outcome Measures

Name	Time	Method
New cardiovascular events (MACE)	3 years

Trial Locations

Locations (1)

Sorlandet Hospital; 🇳🇴 Arendal, Norway