Clinicopathological Characteristics and Prognosis Analysis of Stage IB Non-small Cell Lung Cancer：A Retrospective Real World Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 971
- 试验地点
- 1
- 主要终点
- RFS
研究概览
简要总结
The goal of this observation study is to learn about clinicopathological characteristics and prognostic factors of stage IB NSCLC. The main question it aims to answer is wheather there is relationship between newly proposed clinicopathological features and the prognosis of stage IB NSCLC .The postoperative pathological and follow-up information of participants will be used for subsequent analysis.
详细描述
A total of 971 NSCLC patients with pathological stage IB resected by surgery (R0) from January 2016 to December 2020 at Zhongshan Hospital of Fudan University were reviewed. The primary endpoint is RFS (recurrence-free survival) and OS (overall survival) is the secondary endpoint. The baseline characteristics of the patients were obtained statistically, and factors affecting the prognosis of patients with stage IB NSCLC were analyzed using survival analysis and Cox proportional hazard models. The characteristics of the patients include pathological type, STAS, GGO, gene mutation, and postoperative adjuvant chemotherapy.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •It was confirmed by histopathology as primary non-small cell lung cancer, and the pathological type was LUSC or LUAD;
- •According to the 8th edition of TNM clinical staging standards, it is determined as IB stage
- •No treatment was performed for the primary lesion of lung cancer before surgery;
- •No history of other malignant tumors before surgery;
- •Detailed clinical and pathological information, complete survival data, and no missing follow-up data.
排除标准
- •The postoperative histopathological types include non-scale and non adenocarcinoma, such as lung adenosquamous cell carcinoma, large cell lung cancer, or lung sarcomatoid carcinoma;
- •Multiple lesion staging surgery;
- •History of merging with other malignant tumors
- •Having preoperative treatment;
- •Missing follow-up information.
结局指标
主要结局
RFS
时间窗: 5 years
recurrence-free survival
次要结局
- OS(5 years)