Risk Stratification Using Positron Emission Tomography (PET) in Hypertrophic Cardiomyopathy (HCM)
试验速览
- 阶段
- 不适用
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Ventricular tachycardia (VT) vs myocardial blood flow
研究概览
简要总结
The overall rationale is to reduce the risk of sudden cardiac death in individuals with hypertrophic cardiomyopathy (HCM). The novel approach of this study is to correlate Positron Emission Tomography (PET) findings to ventricular arrhythmias detected by the implantable cardioverter defibrillator (ICD). This could potentially lead to an improved risk stratification of HCM patients.
详细描述
Positron Emission Tomography (PET) is a functional imaging technique that utilizes radioactive tracers to gain information on physiological or pathophysiological processes in vivo. Different tracers can provide information on different processes of interest. In cardiology, metabolic processes consuming oxygen (aerobic) can be studied with 11-Carbon-Acetate, sympathetic innervation can be studied with 11-Carbon-hydroxyephedrine and using 15-Oxygen-water the myocardial blood flow. Structural information of the heart such as left ventricular mass, left ventricular volumes and wall thickness can also be calculated with PET.
The aim is to correlate PET parameters and burden of ventricular arrhythmias in order to improve risk stratification in HCM.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Hypertrophic cardiomyopathy, implantable cardioverter defibrillator, informed consent
排除标准
- •Patients younger than 18 years, pregnancy, breast feeding, claustrophobia, intolerance/allergic reaction to adenosin or mannitol, severe hypotension, unstable angina pectoris, incompensated systolic heart failure, increased intracranial pressure, hypovolemia, dipyramidole.
结局指标
主要结局
Ventricular tachycardia (VT) vs myocardial blood flow
时间窗: History of VT since receiving an implantable defibrillator within last 15 years
Ventricular tachycardia vs positron emissions tomography parameter Myocardial blood flow (MBF)
Ventricular tachycardia (VT) vs ejection fraction
时间窗: History of VT since receiving an implantable defibrillator within last 15 years
Ventricular tachycardia vs positron emissions tomography parameter ejection fraction (EF)
Ventricular tachycardia (VT) vs mass
时间窗: History of VT since receiving an implantable defibrillator within last 15 years
Ventricular tachycardia vs positron emissions tomography parameter mass
Ventricular tachycardia (VT) vs wall thickness
时间窗: History of VT since receiving an implantable defibrillator within last 15 years
Ventricular tachycardia vs positron emissions tomography parameter wall thickness
Ventricular tachycardia (VT) vs oxygen consumption
时间窗: History of VT since receiving an implantable defibrillator within last 15 years
Ventricular tachycardia vs positron emissions tomography parameter oxygen consumption (MVO2)
Ventricular tachycardia (VT) vs sympathetic innervation
时间窗: History of VT since receiving an implantable defibrillator within last 15 years
Ventricular tachycardia vs positron emissions tomography parameter sympathetic innervation (retention index)
Ventricular tachycardia (VT) vs myocardial external efficiency
时间窗: History of VT since receiving an implantable defibrillator within last 15 years
Ventricular tachycardia vs positron emissions tomography parameter myocardial external efficiency (MEE)
Ventricular tachycardia (VT) vs stroke work
时间窗: History of VT since receiving an implantable defibrillator within last 15 years
Ventricular tachycardia vs positron emissions tomography parameter stroke work (SW)
次要结局
- Atrial fibrillation (AF) vs myocardial blood flow(History of VT since receiving an implantable defibrillator within last 15 years)
- Atrial fibrillation (AF) vs ejection fraction(History of VT since receiving an implantable defibrillator within last 15 years)
- Atrial fibrillation (AF) vs mass(History of VT since receiving an implantable defibrillator within last 15 years)
- Atrial fibrillation (AF) vs wall thickness(History of VT since receiving an implantable defibrillator within last 15 years)
- Atrial fibrillation (AF) vs oxygen consumption(History of VT since receiving an implantable defibrillator within last 15 years)
- Atrial fibrillation (AF) vs sympathetic innervation(History of VT since receiving an implantable defibrillator within last 15 years)
- Atrial fibrillation (AF) vs myocardial external efficiency(History of VT since receiving an implantable defibrillator within last 15 years)
- Atrial fibrillation (AF) vs stroke work(History of VT since receiving an implantable defibrillator within last 15 years)
- Atrial size vs ventricular tachycardia(History of VT since receiving an implantable defibrillator within last 15 years)