DRKS00015874Not yet recruitingPhase 4
Reduction of ventilation invasiveness through combined organ support - ADVOVENT (Advanced organ support for reduction of ventilation invasiveness)
niversitätsklinikum Schleswig-Holstein0 sites10 target enrollmentStarted: November 13, 2018Last updated:
Conditions
Trial Snapshot
- Phase
- Phase 4
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 10
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
- Allocation
- N/a: Single Arm Study
- Masking
- Open (masking not used)
Eligibility Criteria
- Ages
- 18 Years to one (—)
- Sex
- All
Inclusion Criteria
- •invasive controlled ventilation at acute hypercapnic respiratory failure (PaCO2 > 45 mmHg)
- •- tidal volume > 6ml/kg ideal weight or driving pressure difference (delta p) > 15 cmH2O required to reach a pH value > 7,30
- •- acute renal failure (KDIGO II or III)
- •- clinical indication for continuous venovenous haemodialysis
- •- consent to participate in the clinical trial
Exclusion Criteria
- •- severe acute hypoxemic respiratory failure (PaO2/FiO2 ratio < 100 mmHg)
- •- moribund status (clinical evaluation)
- •- gravidity
- •- severe haemodynamic instability (heart rate < 40 bpm or > 150 bpm or mean arterial pressure < 65 mmHg or cardiac output < 5 l/min despite adequate therapy)
- •- elevated intracranial pressure
Investigators
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