Male-female differences in immunohistological and biomechanical properties of the thoracic aorta

Recruiting

• Conditions: aortic aneurysm; aortic dilatation; 10002363

• Registration Number: NL-OMON49187
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

Adult patients (>= 18 years old) who have a thoracic aortic aneurysm and are
scheduled for elective thoracic aortic surgery

Exclusion Criteria

Connective tissue disease (e.g. Marfan and Ehlers-Danlos
syndromes)

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Male-female differences in aortic wall structure: smooth muscle cell<br /><br>differentiation, presence of macrophages, endothelial and smooth muscle cell<br /><br>activation and extracellular matrix. Male-female differences in biomechanical<br /><br>properties of the aortic wall (strength and elasticity). Relation of these<br /><br>properties to sex hormone and sRAGE levels in blood and aortic diameter.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable.</p><br>