A Study of Oral Upadacitinib Tablets to Assess Treatment Patterns, Achievement of Treatment Targets and Maintenance of Response in Adult Participants With Moderate to Severe Rheumatoid Arthritis
- Conditions
- Rheumatoid Arthritis (RA)
- Registration Number
- NCT04497597
- Lead Sponsor
- AbbVie
- Brief Summary
Rheumatoid Arthritis (RA) is an inflammatory disease of the joints causing pain, stiffness, swelling and loss of joint function. Despite the range of treatment options for RA steadily increasing, many patients remain sub-optimally managed, with sustained clinical remission rarely achieved. This study will assess the treatment patterns, achievement of treatment targets and maintenance of response.
Upadacitinib is a drug approved for the treatment of moderately to severely active rheumatoid arthritis. Adult participants with moderate to severe RA who have been prescribed upadacitinib by their physicians will be enrolled. Approximately, 1660 participants will be enrolled this study, worldwide.
Participants will not receive Upadacitinib as part of this study, but will be followed for response to treatment for up to 24 months.
There may be higher burden for participants in this trial compared to their standard of care. Participants will attend regular visits, every 3 months, during the course of the study at a hospital or clinic and will be asked to provide additional information by questionnaire at each visit.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1532
- Confirmed diagnosis of moderate to severe active Rheumatoid Arthritis (RA).
- Physician decision on patient treatment with upadacitinib must have been reached prior to and independently of recruitment in the study.
- Upadacitinib prescribed in accordance to the applicable approved label and local regulatory and reimbursement policies.
- French Participants Only: Taking oral glucocorticoids ≥5 mg/day of prednisone or equivalent for at least 3 months prior to study start.
- Prior treatment with Upadacitinib.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Percentage of Participants Who Achieve Remission at 6 Months and Maintain Remission At Month 12 Remission is defined as DAS28-CRP\<2.6. Maintaining remission is defined as no more than 0.6 point increase in DAS28-CRP.
Percentage of Participants Who Achieve Remission At Month 6 Remission is defined as Disease Activity Score at 28 joints (DAS28) C-reactive Protein (CRP)\<2.6.
- Secondary Outcome Measures
Name Time Method Percentage of Participants Who Achieved a Glucocorticoid Dose <5 mg/Day Without Conventional Synthetic Disease Modifying Anti Rheumatic Drug (csDMARD) Intensification At Month 6 Percentage of participants who achieved a glucocorticoid dose \<5 mg/day without csDMARD intensification.
Percentage of Participants Who Achieve Remission at 6 Months and Maintain Remission At Month 24 Remission is defined as DAS28-CRP\<2.6. Maintaining remission is defined as no more than 0.6 point increase in DAS28-CRP.
Percentage of Participants Who Achieve Remission at 3 Months and Maintain Remission Through Month 24 Remission is defined as DAS28-CRP\<2.6. Maintaining remission is defined as no more than 0.6 point increase in DAS28-CRP.
Percentage of Participants in Remission that Achieve Glucocorticoid Dose <5 mg/Day Per Visit Through Month 24 Remission is defined as DAS28-CRP\<2.6.
Percentage of Participants Who Achieve LDA at 3 months that maintain LDA Grouped by Glucocorticoid Dose Through Month 6 LDA is defined as DAS28-CRP≤3.2. Maintaining remission is defined as no more than 0.6 point increase in DAS28-CRP.
Percentage of Participants Who Do Not Achieve Remission at Any Point in the Study Through Month 24 Remission is defined as DAS28-CRP\<2.6.
Time to the Discontinuation of Upadacitinib Through Month 24 Time to the discontinuation of Upadacitinib.
Time to First Treatment Adjustment Baseline (Month 0) Through Month 24 Treatment Adjustment is defined as treatment escalation/de-escalation/ addition/withdrawal.
Percentage of Participants Achieving LDA Grouped by Therapy Strategy Through Month 24 LDA is defined as DAS28-CRP\<3.2, Simplified Disease Activity Index (SDAI) ≤11 and Clinical Disease Activity Index (CDAI) ≤10.
Change in Functional Assessment of Chronic Illness Therapy - Fatigue (FACIT-F) in Participants, Grouped by Therapy Strategy Baseline (Month 0) Through Month 24 The FACIT Fatigue Scale is a short, 13-item, easy to administer tool that measures an individual's level of fatigue during their usual daily activities over the past week. The level of fatigue is measured on a four-point Likert scale (0 = not at all fatigued to 4 = very much fatigued).
Percentage of Participants Who Achieve Low Disease Activity (LDA) at 6 months that maintain LDA Through Month 24 LDA is defined as DAS28-CRP≤3.2. Maintaining remission is defined as no more than 0.6 point increase in DAS28-CRP.
Percentage of Participants Who Achieve Remission at 6 Months and Maintain Remission Grouped by Glucocorticoid Dose At Month 12 Remission is defined as DAS28-CRP\<2.6. Maintaining remission is defined as no more than 0.6 point increase in DAS28-CRP.
Percentage of Participants in LDA that Achieve Glucocorticoid Dose <5 mg/Day Per Visit Through Month 24 LDA is defined as DAS28-CRP\<3.2.
Percentage of Participants Who Initiated Upadacitinib as Combination Therapy (csDMARD +/- Glucocorticoids) That Moved to Monotherapy (+/- Glucocorticoids) Through Week 24 Percentage of participants who initiated Upadacitinib as combination therapy (csDMARD +/- Glucocorticoids) that moved to monotherapy (+/- glucocorticoids).
Of the Participants Initiating Upadacitinib as Monotherapy Therapy (+/- Glucocorticoids) and Achieve Remission at 6 months, the Percentage of Participants that Maintain Remission Grouped by Maintenance of Monotherapy Through Month 24 Remission is defined as DAS28-CRP\<2.6.
Change in Pain Visual Analogue Scale (VAS) in participants, Grouped by Therapy Strategy Baseline (Month 0) Through Month 24 A VAS is used to assess worst joint pain in the past 7 days.
Of the Participants Initiating Upadacitinib as Combination Therapy (csDMARD +/- Glucocorticoids) and Achieve Remission at 6 months, the Percentage of Participants that Maintain Remission Grouped by Maintenance of Combination Therapy Strategy Through Month 24 Remission is defined as DAS28-CRP\<2.6.
Of the Participants Initiating Upadacitinib as Combination Therapy (csDMARD +/- Glucocorticoids) and Achieve LDA at 6 months, the Percentage of Participants that Maintain LDA Grouped by Maintenance of Combination Therapy Strategy Through Month 24 LDA is defined as DAS28-CRP\<3.2.
Of the Participants Initiating Upadacitinib as Monotherapy Therapy (+/- Glucocorticoids) and Achieve LDA at 6 months, the Percentage of Participants that Maintain LDA Grouped by Maintenance of Monotherapy Through Month 24 LDA is defined as DAS28-CRP\<3.2.
Percentage of Participants Achieving Remission Grouped by Therapy Strategy Through Month 24 Remission is defined as DAS28-CRP\<2.6, SDAI≤3.3 and CDAI ≤2.8.
Change in Medication Burden Treatment Burden Questionnaire (TBQ) in Participants, Grouped by Therapy Strategy Through Week 24 The TBQ is composed of 13 items rated on a Likert scale ranging from 0 (not a problem), to 10 (big problem). scores can be summed into a global score, ranging from 0 to 130.
Change in Physical Function Health Assessment Questionnaire - Disability Index (HAQ-DI) in Participants, Grouped by Therapy Strategy Baseline (Month 0) Through Month 24 HAQ is a widely accepted, validated, rheumatology specific instrument to assess physical function in Rheumatoid Arthritis. It consists of 20 questions, covering eight types of activities. For each question, scores range from 0 to 3 (0 = without any difficulty; 1 = with some difficulty; 2 = with much difficulty or with assistance; 3 = unable to do). HAQ Disability Index (HAQ-DI) score is the average of the highest score in each of the eight categories.
Change in Morning Stiffness in Participants, Grouped by Therapy Strategy Baseline (Month 0) Through Month 24 A numeric rating scale (NRS) is used to assess severity and length of morning stiffness in the past 7 days.
Trial Locations
- Locations (263)
Hillel Yaffe Medical Center /ID# 222170
🇮🇱Hadera, H_efa, Israel
Rambam Health Care Campus /ID# 222118
🇮🇱Haifa, H_efa, Israel
Galilee Medical Center /ID# 222113
🇮🇱Nahariya, HaTsafon, Israel
Azienda Ospedaliera Civico Di Cristina Benfratelli- P.O. Civico /ID# 228912
🇮🇹Palermo, Italy
Azienda Ospedaliera Universitaria Friuli Centrale/Presidio Ospedaliero Universit /ID# 228551
🇮🇹Udine, Italy
Azienda Ospedaliera Universitaria di Verona/Ospedale Borgo Trento /ID# 228553
🇮🇹Verona, Italy
Republican hospital named after V.A. Baranov /ID# 227661
🇷🇺Petrozavodsk, Russian Federation
Clinic of Samara State Medical University /ID# 241168
🇷🇺Samara, Russian Federation
Budgetary Institution of the Khanty-Mansiysk Autonomous Okrug-Yugra Surgut Dist /ID# 243313
🇷🇺Surgut, Russian Federation
Hospital Universitario Virgen de las Nieves /ID# 231841
🇪🇸Granada, Spain
Drt Sulaiman Al Habib Hospital /ID# 226575
🇦🇪Dubai, United Arab Emirates
Asociacion Española /ID# 222009
🇺🇾Montevideo, Uruguay
CER Instituto Medico /ID# 222193
🇦🇷Quilmes, Buenos Aires, Argentina
Klinikum Klagenfurt am Wörthersee /ID# 239628
🇦🇹Klagenfurt am Wörthersee, Kaernten, Austria
Rheuma-Zentrum Wien-Oberlaa GmbH /ID# 227853
🇦🇹Vienna, Wien, Austria
Instituto CAICI S.R.L /ID# 222191
🇦🇷Rosario, Santa Fe, Argentina
University General Hospital Attikon /ID# 224136
🇬🇷Athens, Attiki, Greece
Saudi German Hospital Jeddah /ID# 243234
🇸🇦Jeddah, Saudi Arabia
China Medical University Hospital /ID# 241051
🇨🇳Taichung, Taiwan
HFR Fribourg - Hôpital cantonal /ID# 224163
🇨🇭Fribourg, Switzerland
Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 241052
🇨🇳Kaohsiung, Taiwan
Integrated Rheumatology and Arthritis Center /ID# 223177
🇦🇪Dubai, United Arab Emirates
Cabinet Novel d'Annecy /ID# 232310
🇫🇷Annecy, France
Tallaght University Hospital /ID# 231260
🇮🇪Tallaght, Dublin, Ireland
St James Hospital /ID# 224201
🇮🇪Dublin 8, Dublin, Ireland
Universitätsspital Basel /ID# 224160
🇨🇭Basel Town, Basel-Stadt, Switzerland
Cabinet médical /ID# 225000
🇫🇷Les Abrets En Dauphine, Isere, France
Hopitaux Universitaires Paris Centre-Hopital Cochin /ID# 222986
🇫🇷Paris CEDEX 14, Paris, France
CHU Strasbourg - Hopital de Hautepierre /ID# 222450
🇫🇷Strasbourg, Bas-Rhin, France
Joint West Rheumatology /ID# 223886
🇦🇺Murdoch, Western Australia, Australia
Private Practice - Scott Walter Graf /ID# 223958
🇦🇺Adelaide, South Australia, Australia
CH Emile Roux Le Puy en Velay /ID# 223688
🇫🇷Le Puy en Velay, France
The Lady Davis Carmel Medical Center /ID# 223851
🇮🇱Haifa, H_efa, Israel
Hospital Italiano La Plata /ID# 222190
🇦🇷La Plata, Buenos Aires, Argentina
Organizacion Medica de Investigacion (OMI) /ID# 222187
🇦🇷Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina
CIER Centro de Investigaciones en Enfermedades Reumaticas /ID# 231769
🇦🇷Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina
DOM Centro de Reumatologia /ID# 222194
🇦🇷Buenos Aires, Argentina
CIMER Centro Integral de Medicina Respiratoria /ID# 222188
🇦🇷San Miguel de Tucuman, Tucuman, Argentina
Instituto Medico Strusberg /ID# 222189
🇦🇷Cordoba, Argentina
Instituto de Cardiologia /ID# 226634
🇦🇷Santiago Del Estero, Argentina
Genesis Research Services /ID# 224060
🇦🇺Broadmeadow, New South Wales, Australia
Emeritus Research /ID# 223883
🇦🇺Camberwell, Victoria, Australia
BJC Health /ID# 223884
🇦🇺Paramatta, New South Wales, Australia
Ordination Dr. Leeb /ID# 224293
🇦🇹Hollabrunn, Niederoesterreich, Austria
Dr. Georg Kurtz /ID# 225477
🇦🇹Gleisdorf, Steiermark, Austria
Ordination Doz. Grisar /ID# 224298
🇦🇹Vienna, Wien, Austria
Dr. Maya Thun /ID# 224299
🇦🇹Vienna, Wien, Austria
Rhumaconsult SPRL /ID# 221825
🇧🇪Charleroi, Hainaut, Belgium
CHU Saint Pierre /ID# 223041
🇧🇪Bruxelles, Bruxelles-Capitale, Belgium
Algemeen Stedelijk Ziekenhuis /ID# 224121
🇧🇪Aalst, Oost-Vlaanderen, Belgium
Duplicate_CHU UCL Namur - site Godinne /ID# 222797
🇧🇪Godinne, Namur, Belgium
Reuma Instituut Hasselt /ID# 221822
🇧🇪Hasselt, Limburg, Belgium
Private practice Sint-Niklaas /ID# 224123
🇧🇪Sint-Niklaas, Oost-Vlaanderen, Belgium
Onze Lieve Vrouw Hospital /ID# 223042
🇧🇪Aalst, Belgium
AZ Sint-Jan Brugge /ID# 223713
🇧🇪Brugge, Belgium
AZ Sint Lucas /ID# 223093
🇧🇪Brugge, Belgium
Reumacentrum /ID# 222799
🇧🇪Genk, Belgium
AZ Alma Campus Sijsele /ID# 222214
🇧🇪Sijsele, Belgium
Centre Hospitalier de CHOLET /ID# 222455
🇫🇷Cholet, France
Maertens, Gistel, BE /ID# 221823
🇧🇪Gistel, Belgium
ReumaClinic /ID# 221353
🇧🇪Genk, Belgium
CHU de Liege /ID# 222201
🇧🇪Liege, Belgium
Centre Hospitalier de Laon /ID# 224857
🇫🇷Laon CEDEX, Aisne, France
Polyclinique saint Odilon /ID# 225576
🇫🇷Moulins, Allier, France
CHU Dijon /ID# 223799
🇫🇷Dijon, Cote-d Or, France
CH Cannes - les Broussailles /ID# 226160
🇫🇷Cannes CEDEX, Alpes-Maritimes, France
Hopital Saint Joseph /ID# 227221
🇫🇷Marseille, Bouches-du-Rhone, France
cabinet liberal- Dr CORNILLE /ID# 227869
🇫🇷Caen, Calvados, France
Centre Hospitalier d'Angouleme /ID# 226064
🇫🇷Angouleme CEDEX 9, Charente, France
Cabinet de rhumatologie /ID# 227740
🇫🇷Mennecy, Essonne, France
CH Georges Renon /ID# 225197
🇫🇷Niort CEDEX, Deux-Sevres, France
CH des Pays de Morlaix /ID# 223795
🇫🇷Morlaix, Finistere, France
CHU de Besancon - Jean Minjoz /ID# 222463
🇫🇷Besancon, Doubs, France
CHU Limoges - Dupuytren 1 /ID# 222457
🇫🇷Limoges CEDEX 1, Franche-Comte, France
CHU Bordeaux - Hopital Pellegrin /ID# 224837
🇫🇷Bordeaux, Gironde, France
Cabinet Rhumatologie St Michel Sur Orge /ID# 225176
🇫🇷St Michel Sur Orge, Essonne, France
Hopital de la Cavale Blanche /ID# 222462
🇫🇷Brest, Finistere, France
CHU Toulouse - Hopital Purpan /ID# 223150
🇫🇷TOULOUSE Cedex 9, Haute-Garonne, France
CH Bigorre - Site de la Gespe /ID# 225141
🇫🇷Tarbes CEDEX 9, Hautes-Pyrenees, France
CH Roubaix - Hopital Victor Provo /ID# 225032
🇫🇷Roubaix Cedex 1, Hauts-de-France, France
CHU Montpellier - Hopital Saint Eloi /ID# 222452
🇫🇷Montpellier Cedex 5, Herault, France
Clinique Beau Soleil /ID# 224238
🇫🇷Montpellier, Herault, France
Hopital Avicenne - APHP /ID# 224248
🇫🇷Bobigny, Ile-de-France, France
CHU Montpellier - Hopital Saint Eloi /ID# 223394
🇫🇷Montpellier Cedex 5, Herault, France
CHU Grenoble - Hopital Michallon /ID# 223211
🇫🇷La Tronche, Isere, France
CH Roanne /ID# 224729
🇫🇷Roanne, Loire, France
Cabinet médical /ID# 225321
🇫🇷Reims, Marne, France
Cabinet de Rhumatologie Poincare /ID# 224755
🇫🇷Thionville, Moselle, France
Cabinet liberal - Compiegne - Dr Banse /ID# 227099
🇫🇷Compiegne, Oise, France
CHU de Nantes, Hotel Dieu -HME /ID# 225787
🇫🇷Nantes, Pays-de-la-Loire, France
Cabinet medical /ID# 224850
🇫🇷Albi, Tarn, France
CHU Nice -Hopital Pasteur /ID# 222460
🇫🇷Nice CEDEX 1, Provence-Alpes-Cote-d Azur, France
HCL - Hopital Lyon Sud /ID# 222447
🇫🇷Pierre Benite CEDEX, Rhone, France
Infirmerie Protestante /ID# 222438
🇫🇷Caluire Et Cuire, Rhone, France
Cabinet libéral du Dr PAUPIERE /ID# 238723
🇫🇷Peronne, Somme, France
Cabinet medical /ID# 225366
🇫🇷Aix les Bains, Savoie, France
CHU Amiens-Picardie Site Sud /ID# 222444
🇫🇷Amiens CEDEX 1, Somme, France
CHD Vendée- La Roche-sur-Yon - Les Oudairies /ID# 229086
🇫🇷La Roche Sur Yon, Vendee, France
Centre Hospitalier d'Arras /ID# 223172
🇫🇷Arras, France
Centre Hospitalier de Boulogne Sur Mer /ID# 222991
🇫🇷Boulogne sur Mer, France
CH du Pays d'AIX /ID# 229561
🇫🇷Aix En Provence Cedex 1, France
Centre Hospitalier Jean Rougie /ID# 224242
🇫🇷Cahors, France
CHRU Tours - Hopital Trousseau /ID# 222445
🇫🇷Chambray Les Tours, France
Hia Percy /Id# 225642
🇫🇷Clamart, France
CHU Clermont Ferrand - Hopital Gabriel Montpied /ID# 223801
🇫🇷Clermont Ferrand, France
Cabinet medical /ID# 225142
🇫🇷Haguenau, France
C. H. Sud Francilien /ID# 222446
🇫🇷Corbeil Essonnes, France
CH La Rochelle - Hopital Saint Louis /ID# 224240
🇫🇷La Rochelle, France
CHU Lille - Hôpital Roger Salengro /ID# 223170
🇫🇷Lille, France
Clinique de la Sauvegarde /ID# 223424
🇫🇷Lyon, France
CH Princesse Grace /ID# 222451
🇫🇷Monaco, France
Ch Montauban /Id# 231854
🇫🇷Montauban, France
ELSAN - Clinique du Pont de Chaume /ID# 224898
🇫🇷Montauban, France
Ch Mulhouse /Id# 223442
🇫🇷Mulhouse, France
Centre Hospitalier Régional d'Orléans - Hôpital de la Source /ID# 223591
🇫🇷Orléans, France
Hopital Pitie Salpetriere /ID# 222443
🇫🇷Paris, France
AP-HP - Hopital Bichat - Claude-Bernard /ID# 222449
🇫🇷Paris, France
AP-HP - Hopital Saint-Antoine /ID# 222441
🇫🇷Paris, France
Centre de Soins Osteoarticulaires Ambulatoires /ID# 224737
🇫🇷Paris, France
Hôpital Charles-Nicolle /ID# 223589
🇫🇷Rouen, France
GH Diaconesses Croix Saint-Simon /ID# 229126
🇫🇷Paris, France
Cabinet medical /ID# 224855
🇫🇷Paris, France
Hôpital d'instruction des armées Bégin /ID# 222440
🇫🇷Saint-Mandé cedex, France
CH Saint Nazaire /ID# 225750
🇫🇷St Nazaire, France
CHU de Rennes - Hospital Sud /ID# 222458
🇫🇷Rennes CEDEX 2, France
Clinique Saint-Hilaire /ID# 223833
🇫🇷Rouen, France
Cabinet rhumatologie Dr NECTOUX /ID# 225828
🇫🇷Sainte Maxime, France
Centre Hospitalier Universitaire de Saint Étienne - Hôpital Nord /ID# 222456
🇫🇷St-Priest-en-Jarez, France
ACURA Rheumazentrum Baden-Bade /ID# 225225
🇩🇪Baden-baden, Germany
Groupe Médical Spécialisé - Le Premium /ID# 223719
🇫🇷Strasbourg, France
Rheumatologische-Immunologische Praxis Templin /ID# 226924
🇩🇪Templin, Brandenburg, Germany
Praxis Dr. Haas /ID# 225187
🇩🇪Tuebingen, Baden-Wuerttemberg, Germany
Praxis fuer Rheumatologie und Innere Medizin /ID# 225222
🇩🇪Berlin, Germany
Rheumatologie in Veedel /ID# 224999
🇩🇪Cologne, Germany
Rheumapraxis Prof Dr Karin Manger /ID# 224086
🇩🇪Bamberg, Germany
Eisterhues, Braunschweig, DE /ID# 225186
🇩🇪Braunschweig, Germany
Praxis Dilltal /ID# 226925
🇩🇪Ehringshausen, Germany
Heilig, Heidelberg, DE /ID# 225223
🇩🇪Heidelberg, Germany
Dres. Karger/Baerlecken /ID# 224809
🇩🇪Cologne, Germany
MVZ Ambulantes Rheumazentrum Erfurt /ID# 224812
🇩🇪Erfurt, Germany
Praxis internistische Rheumatologie /ID# 239226
🇩🇪Leipzig, Germany
Asklepios MVZ Nord SH GmbH /ID# 225048
🇩🇪Hamburg, Germany
Helios Fachklinik Vogelsang-Gommern /ID# 222949
🇩🇪Gommern, Germany
Dres. Teipel/Toussaint/Saech /ID# 226923
🇩🇪Leverkusen, Germany
Die Fachaerzte im Rottal - Nephrologie, Rheumatologie /ID# 223866
🇩🇪Pfarrkirchen, Germany
Aurich & Sieburg, Magdeburg /ID# 230701
🇩🇪Magdeburg, Germany
Olympion General Clinic /ID# 224130
🇬🇷Patras, Achaia, Greece
MVZ für Rheumatologie Dr. M. Welcker /ID# 226926
🇩🇪Planegg, Germany
Krankenhaus der Barmherzigen Brüder Trier /ID# 226927
🇩🇪Trier, Germany
251 Airforce General Hospital /ID# 225065
🇬🇷Athens, Attiki, Greece
General Hospital of Athens Gennimatas /ID# 225064
🇬🇷Athens, Attiki, Greece
General Hospital of Athens Ippokratio /ID# 224164
🇬🇷Athens, Attiki, Greece
University General Hospital of Alexandroupolis /ID# 224880
🇬🇷Alexandroupoli, Evros, Greece
University General Hospital of Heraklion PA.G.N.I /ID# 224133
🇬🇷Heraklion, Kriti, Greece
General Hospital Asklepieio Voulas /ID# 224131
🇬🇷Athens, Attiki, Greece
Naval Hospital of Athens /ID# 224135
🇬🇷Athens, Greece
Bioclinic Thessaloniki /ID# 224879
🇬🇷Thessaloniki, Greece
General Hospital of Patras Agios Andreas /ID# 224132
🇬🇷Patras, Greece
St Vincent's University Hospital /ID# 224200
🇮🇪Elm Park, Dublin, Ireland
General Hospital of Thessaloniki Hippokrateio /ID# 229965
🇬🇷Thessaloniki, Greece
Euromedica General Clinic /ID# 224134
🇬🇷Thessaloniki, Greece
Hermitage Medical Clinic /ID# 239556
🇮🇪Dublin 20, Dublin, Ireland
HaEmek Medical Center /ID# 222138
🇮🇱Afula, H_efa, Israel
Meir Medical Center /ID# 222116
🇮🇱Kfar Saba, HaMerkaz, Israel
Rabin Medical Center /ID# 222694
🇮🇱Haifa, Israel
The Chaim Sheba Medical Center /ID# 222034
🇮🇱Ramat Gan, Tel-Aviv, Israel
Azienda Ospedaliero Universitaria Ospedali Riuniti Do Ancona /ID# 229440
🇮🇹Torette, Ancona, Italy
Tel Aviv Sourasky Medical Center /ID# 222117
🇮🇱Tel Aviv, Tel-Aviv, Israel
ASL 3 Genovese - Ospedale la Colletta /ID# 228892
🇮🇹Arenzano, Genova, Italy
Azienda Ospedaliero Universitaria di Ferrara - Ospedale Sant'Anna /ID# 228788
🇮🇹Cona, Ferrara, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Universita Cattolica /ID# 229061
🇮🇹Rome, Lazio, Italy
Ospedale San Raffaele IRCCS /ID# 229059
🇮🇹Milan, Milano, Italy
ASST Grande Ospedale Metropolitano Niguarda /ID# 228807
🇮🇹Milan, Milano, Italy
Istituto Clinico Humanitas /ID# 227943
🇮🇹Rozzano, Milano, Italy
Sapienza University /ID# 228014
🇮🇹Rome, Roma, Italy
Fondazione Policlinico Universitario Campus Bio-Medico di Roma /ID# 229063
🇮🇹Rome, Roma, Italy
Ospedale Mauriziano di Torino /ID# 228888
🇮🇹Turin, Torino, Italy
Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo /ID# 228889
🇮🇹Alessandria, Italy
Azienda Ospedaliera Universitaria Consorziale Policlinico /ID# 228580
🇮🇹Bari, Italy
ASST Spedali civili di Brescia /ID# 228970
🇮🇹Brescia, Italy
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII (Presidio Papa Giovanni /ID# 228967
🇮🇹Bergamo, Italy
Ospedale Ss. Annunziata /ID# 228809
🇮🇹Chieti, Italy
Azienda Ospedaliero-Universitaria di Modena /ID# 228554
🇮🇹Modena, Italy
AOU Universita degli Studi della Campania Luigi Vanvitelli /ID# 229057
🇮🇹Napoli, Italy
Ospedale San Giovanni Bosco /ID# 228552
🇮🇹Napoli, Italy
ASST Gaetano Pini/Presidio Ospedaliero Pini /ID# 228556
🇮🇹Milan, Italy
Azienda Ospedaliera Universitaria Paolo Giaccone /ID# 228160
🇮🇹Palermo, Italy
Azienda Ospedaliera Regionale San Carlo /ID# 228648
🇮🇹Potenza, Italy
Azienda Ospedaliero Universitaria Pisana /ID# 228550
🇮🇹Pisa, Italy
Fondazione IRCCS Policlinico /ID# 227937
🇮🇹Pavia, Italy
Azienda Ospedaliero-Universitaria Sant'Andrea /ID# 227942
🇮🇹Rome, Italy
Azienda Ospedaliera Universitaria "San Giovanni di Dio e Ruggi d'Aragona /ID# 229065
🇮🇹Salerno, Italy
Azienda Ospedaliero-Universitaria Senese-Ospedale Santa Maria delle Scotte /ID# 227938
🇮🇹Siena, Italy
Mubarak Hospital /ID# 224139
🇰🇼Hawalli, Kuwait
Ameeri Hospital /ID# 224140
🇰🇼Kuwait City, Kuwait
KOC Hospital /ID# 224138
🇰🇼Kuwait, Kuwait
Centro Integral en Reumatologia S.A de C.V /ID# 224363
🇲🇽Guadalajara, Jalisco, Mexico
CINTRE, Centro de Investigación y Tratamiento Reumatológico SC /ID# 240836
🇲🇽Mexico City, Ciudad De Mexico, Mexico
Private Office Dr. Orozco /ID# 243257
🇲🇽Guadalajara, Jalisco, Mexico
Clinica de Investigacion en Reumatologia y Obesidad S.C. /ID# 224361
🇲🇽Guadalajara, Jalisco, Mexico
RM Pharma Specialists S.A de C.V. /ID# 224359
🇲🇽Mexico City, Ciudad De Mexico, Mexico
Centro de Estudios de Investigación Básica y Clínica, S.C. /ID# 224364
🇲🇽Guadalajara, Jalisco, Mexico
Consultorio Medico Privado - Miryam Eguia Bernal /Id# 243255
🇲🇽Monterrey, Nuevo Leon, Mexico
Centro Especializado en Diabetes, Obesidad y Prevencion de Enfermedades Cardiova /ID# 224360
🇲🇽Mexico City, Mexico
Nort-Western State Medical University n.a. Mechnikov /ID# 223419
🇷🇺St. Petersburg, Sankt-Peterburg, Russian Federation
Moscow Regional Research and Clinical Institute n.a. Vladimirskiy (MONIKI) /ID# 224852
🇷🇺Moscow, Moskovskaya Oblast, Russian Federation
LLC MC RevmaMed /ID# 239162
🇷🇺Syktyvkar, Komi, Respublika, Russian Federation
Consultorio Privado Jorge Rojas Serrano /Id# 243258
🇲🇽Puebla, Mexico
Samara Regional Clinical Hospital n.a. V. D. Seredavin /ID# 227852
🇷🇺Samara, Samarskaya Oblast, Russian Federation
GBUZ TO Regional Clinical Hospital No. 1 /ID# 241113
🇷🇺Tyumen, Tyumenskaya Oblast, Russian Federation
District clinical hospital /ID# 227662
🇷🇺Khanty-Mansyisk, Russian Federation
Orenburg State Medical University /ID# 243615
🇷🇺Orenburg, Russian Federation
City Clinical Hospital #52 /ID# 242947
🇷🇺Moscow, Russian Federation
Omsk Regional Clinic Hospital /ID# 232029
🇷🇺Omsk, Russian Federation
Nebbiolo Clinical Research Center /ID# 224900
🇷🇺Tomsk, Russian Federation
Military Medical Academy n.a. Kirov /ID# 242351
🇷🇺St. Petersburg, Russian Federation
Ulyanovsk Regional Clinical Hospital /ID# 239164
🇷🇺Ulyanovsk, Russian Federation
Voronezh State Medical Univers /ID# 224854
🇷🇺Voronezh, Russian Federation
Clinical Rheumatologic Hospital No 25 /ID# 242475
🇷🇺St. Petersburg, Russian Federation
Yaroslavl State Medicat University /ID# 224851
🇷🇺Yaroslavl, Russian Federation
King Fahad Medical City /ID# 222917
🇸🇦Riyadh, Saudi Arabia
King Abdulaziz University Hospital /ID# 222724
🇸🇦Jeddah, Saudi Arabia
Saudi German Hospital /ID# 224137
🇸🇦Mushait, Saudi Arabia
International Medical Center /ID# 243235
🇸🇦Jeddah, Saudi Arabia
Complejo Hospitalario Universitario A Coruña /ID# 231818
🇪🇸A Coruña, A Coruna, Spain
Hospital de Mérida /ID# 231826
🇪🇸Mérida, Badajoz, Spain
Hospital Universitari Mútua Terrassa /ID# 231822
🇪🇸Terrassa, Barcelona, Spain
Hospital de Viladecans /ID# 231823
🇪🇸Viladecans, Barcelona, Spain
Hospital Virgen del Puerto /ID# 240149
🇪🇸Plasencia, Caceres, Spain
Hospital Universitario de Jerez de la Frontera /ID# 231844
🇪🇸Jerez de la Frontera, Cadiz, Spain
Hospital Universitario Reina Sofia /ID# 231843
🇪🇸Córdoba, Cordoba, Spain
Hospital Universitario de Getafe /ID# 231825
🇪🇸Getafe, Madrid, Spain
Hospital General Universitario Santa Lucia /ID# 238780
🇪🇸Cartagena, Murcia, Spain
Hospital Clinico Universitario Virgen de la Arrixaca /ID# 231847
🇪🇸El Palmar, Murcia, Spain
Hospital Rafael Mendez /ID# 231846
🇪🇸Lorca, Murcia, Spain
Hospital Xeral Cies (CHUVI) /ID# 231819
🇪🇸Vigo, Pontevedra, Spain
Hospital Universitario Canarias /ID# 231848
🇪🇸San Cristóbal de La Laguna, Santa Cruz De Tenerife, Spain
Hospital Universitario Torrecardenas /ID# 241931
🇪🇸Almeria, Spain
Hospital Parc de Salut del Mar /ID# 240000
🇪🇸Barcelona, Spain
Hospital Perpetuo Socorro /ID# 231827
🇪🇸Badajoz, Spain
Hospital Ernest Lluch Martin /ID# 238779
🇪🇸Calatayud, Zaragoza, Spain
Hospital Santa Creu i Sant Pau /ID# 231821
🇪🇸Barcelona, Spain
Hospital General de Granollers /ID# 238778
🇪🇸Barcelona, Spain
Hospital Juan Ramon Jimenez /ID# 231840
🇪🇸Huelva, Spain
Hospital Universitario de Jaen /ID# 231842
🇪🇸Jaen, Spain
Hospital Universitario Ramon y Cajal /ID# 241901
🇪🇸Madrid, Spain
Hospital Universitario Virgen de la Victoria /ID# 240150
🇪🇸Malaga, Spain
Hospital Universitario Virgen Macarena /ID# 231837
🇪🇸Sevilla, Spain
Hospital Universitario Virgen de Valme /ID# 231838
🇪🇸Sevilla, Spain
Kantonsspital Aarau AG /ID# 222354
🇨🇭Aarau, Aargau, Switzerland
Hospital Universitario Virgen del Rocio /ID# 231836
🇪🇸Sevilla, Spain
Hospital Royo Villanova /ID# 231824
🇪🇸Zaragoza, Spain
Kantonsspital St. Gallen /ID# 224158
🇨🇭St. Gallen, Sankt Gallen, Switzerland
Rheumatologisches Versorgungszentrum Weinfelden /ID# 222346
🇨🇭Weinfelden, Thurgau, Switzerland
Inselspital, Universitaetsspital Bern /ID# 224951
🇨🇭Bern, Switzerland
CHUV, Centre hospitalier universitaire vaudois /ID# 224161
🇨🇭Lausanne, Vaud, Switzerland
National Taiwan University Hospital /ID# 241050
🇨🇳Taipei City, Taipei, Taiwan
Chi-Mei Medical Center /ID# 241745
🇨🇳Tainan, Taiwan
Tri-Service General Hospital /ID# 241746
🇨🇳Taipei City, Taiwan
Linkou Chang Gung Memorial Hospital /ID# 241053
🇨🇳Taoyuan City, Taiwan
Cleveland Clinic Abu Dhabi /ID# 223176
🇦🇪Abu Dhabi, United Arab Emirates
Departnent of Medicine-Rheumatology Al Baraha Hospital and Al Qasmi Hospital Min /ID# 223178
🇦🇪Dubai, United Arab Emirates
Medica Uruguaya /ID# 222008
🇺🇾Montevideo, Uruguay