QUANTACT : Impact of Pangenomic QUANTitative Alterations in Cancer Therapy
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 1,200
- 试验地点
- 1
- 主要终点
- Number of targeted molecular alterations
研究概览
简要总结
"Precision medicine and targeted therapies have played a crucial role over the past ten years in the personalized care of cancer patients. In this retrospective and observational study, we focused on patients for which no standard or curative treatment was available and for which the management was discussed in a Molecular Tumor Board (MTB).
The role of the MTB is to decide the most appropriate therapeutic options for patients according to the potential identification of molecular targets.
Among the analyses carried out, we focused on a quantitative genome-wide analysis: the CGH/SNP-array (Comparative Genomic Hybridization / Single Nucleotide Polymorphism on array). The objective was to evaluate the impact of CGH/SNP-array analyses in the identification of targeted molecular alterations.
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研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histologically or cytologically confirmed solid tumor malignancy that is advanced or metastatic ;
- •no standard or curative treatment available;
- •non-opposition of the patient collected.
排除标准
- •multiple cancer patient;
- •ECOG Scale of Performance Status (PS) ≥2
结局指标
主要结局
Number of targeted molecular alterations
时间窗: at day 0
Number of targeted molecular alterations
次要结局
- Number of patients eligible for targeted therapy (clinical trials or "off-label" drug)(at day 0)