Single Dose Cefepime Versus Cefuroxime Plus Metronidazole as a Prophylactic Antibiotic: A Randomized Controlled Study
试验速览
- 阶段
- 2 期
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- Incidence of surgical site wound infection
研究概览
简要总结
Compare between cefepime versus routine antibiotics as a prophylactic antibiotic during emergency cesarean section in a tertiary center of obstetric care
详细描述
This is a randomized double blinded study which compare between single dose cefepime versus cefuroxime plus metronidazole during emergency intrapartum cesarean section.
Outcomes will include fever, wound infection, and urinary tract infection.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •intrapartum caesarean section
排除标准
- •evidence of infection
研究组 & 干预措施
"Cefepime" , "Maxipime®" 1 gm
Patient will receive "Cefepime" ,"Maxipime®" 1 gm IV during cesarean section just before skin incision
干预措施: Cefepime (Drug)
"Cefuroxime", "Zinnat®" 1gm plus "metronidazole"Flagyl®" 500
Patient will receive "Cefuroxime", "Zinnat®" 1gm ,and "metronidazole"Flagyl®" 500 IV; just before skin incision for emergency cesarean section
干预措施: Cefuroxime plus Metronidazole (Drug)
结局指标
主要结局
Incidence of surgical site wound infection
时间窗: one week
Examining the wound after one week of the surgery to detect any infection
次要结局
未报告次要终点
研究者
Osama Saber Thabet Abdalmageed
Consultant of Obstetrics and gynecology
Assiut University