Effect of Granulocyte colony stimulating factor (G-CSF) on survival of children with Acute on Chronic Liver Failure
Not Applicable
- Conditions
- Health Condition 1: null- Children diagnosed with Acute on Chronic Liver Failure, presenting with or without Hepatic Encephalopathy Grade 1 or Grade 2
- Registration Number
- CTRI/2017/11/010420
- Lead Sponsor
- Departmental Fund
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Jaundice and coagulopathy, complicated within 4 weeks by ascites and/or encephalopathy.
2.Evidence of chronic liver disease on history/examination/investigations
3.Jaundice [serum bilirubin >5 mg/dl]
4.Coagulopathy (INR >1.5/prothrombin activity <40%).
5.Complicated within 4 weeks by ascites and/or encephalopathy (as determined by clinical examination).
Exclusion Criteria
1.Previous episodes of Decompensated cirrhosis
2.Tropical infection related hepatopathy with high grade fever
3.Age of <1 year
4.Portal vein thrombosis
5.Severe sepsis/ Multi-organ failure at presentation
6.Grade 3 or 4 hepatic encephalopathy
7.HIV seropositive
8.Any previous known hypersensitivity to G-CSF
9.Any significant comorbidity
10. Refusal to participate in the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method