ISRCTN44723643已完成未知
Safety of discontinuing co-trimoxaxole prophylaxis among human immunodeficiency virus (HIV) infected adults in Uganda: a randomised controlled trial
MRC/UVRI Uganda Research Unit on AIDS (Uganda)0 个研究点目标入组 2,000 人开始时间: 2010年8月27日最近更新:
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 2,000
研究概览
简要总结
2016 Incidence of malari results in: https://www.ncbi.nlm.nih.gov/pubmed/26558729 2016 Longitudinal effect results in: https://www.ncbi.nlm.nih.gov/pubmed/27417903 2017 Effect of antiretroviral therapy results in: https://www.ncbi.nlm.nih.gov/pubmed/28121670 2020 immunology substudy results in https://pubmed.ncbi.nlm.nih.gov/31714954/ (added 17/02/2021)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Human immunodeficiency virus (HIV) infected patient taking co-trimoxazole for at least 6 months
- •2. Aged 18 - 59 years, either sex
- •3. Documented intake of ART for at least 6 months
- •4. Clinically asymptomatic
- •5. Two CD4 counts (not more than 6 months apart) greater than or equal to 250 cells/mm3, the most recent no more than 4 weeks prior to enrolment
- •6. Able to attend 3-monthly study clinics for appointments and in event of intercurrent illness
排除标准
- •1. Acute illness (opportunistic infection or other co- morbidity). Patients will be considered for inclusion into the trial after resolution of the illness.
- •2. First trimester pregnancy. Pregnant women who reach their second trimester of pregnancy could then be re-evaluated for inclusion into the trial.
- •3. Known hypersensitivity to co-trimoxazole
研究者
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