VCRC Tissue Repository

Recruiting

• Conditions: Aortitis; Eosinophilic Granulomatosis With Polyangiitis; Granulomatosis With Polyangiitis (Wegener's); Henoch-Schonlein Purpura; Polyarteritis Nodosa; Churg-Strauss Syndrome; IgA Vasculitis; Microscopic Polyangiitis; Takayasu Arteritis; Cutaneous Vasculitis

• Registration Number: NCT02967068
• Lead Sponsor: University of Pennsylvania

Brief Summary

The purpose of this study is to collect existing tissue specimens from subjects enrolled in Vasculitis Clinical Research Consortium (VCRC) studies. Analysis of these tissue specimens and linked clinical data collected through VCRC studies may lead to the identification and development of a series of translational research projects. Results of these studies will provide vasculitis researchers with insight into the causes of these diseases and generate new ideas for diagnostic tests and therapies, and will be of great interest to the larger communities of researchers investigating vasculitis and other autoimmune, inflammatory, and vascular diseases.

Detailed Description

Biopsy specimens collected as standard of care for these diseases will be retrieved and used in research. The most common biopsies performed are kidney, lung, skin, nerves, and vessels; however, other tissue is also of interest for the study. Biopsies are not performed as part of this protocol, rather we will request consent to collect biopsy specimens already collected under routine care.

Study Timeline

• Study Start: 2016-11
• Study First Submitted: 2016-11-11
• Study First Submitted QC: 2016-11-15
• Study First Posted: 2016-11-17
• Status Verified: 2024-01
• Last Update Submitted: 2024-01-23
• Last Update Posted: 2024-01-25
• Primary Completion: 2025-12
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

• A participant will be deemed eligible for this study if the participant is/was enrolled in another one of the VCRC observational/longitudinal protocols (5502, 5503, 5504, 5505, 5506, 5507, 5563) and/or one of the VCRC interventional studies (5522, 5523, 5526, 5527, or 5562).

Read More

Exclusion Criteria

• Inability to give informed consent (or their guardians in the case of children) and to sign the consent form.
• Unwilling to allow the use of their tissue for research.

Read More

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Identify genes that increase the risk of developing vasculitis	1 year	Evaluating of clinical data and linked biopsy specimens to identify genes that increase the risk of developing vasculitis.

Trial Locations

Locations (8)

University of Pennsylvania; 🇺🇸 Philadelphia, Pennsylvania, United States

University of Pittsburgh; 🇺🇸 Pittsburgh, Pennsylvania, United States

Cleveland Clinic; 🇺🇸 Cleveland, Ohio, United States

University of Utah; 🇺🇸 Salt Lake City, Utah, United States

University of Toronto Mount Sinai Hospital; 🇨🇦 Toronto, Ontario, Canada

Brigham and Women's Hospital; 🇺🇸 Boston, Massachusetts, United States

Boston University School of Medicine; 🇺🇸 Boston, Massachusetts, United States

St. Joseph's Healthcare; 🇨🇦 Hamilton, Ontario, Canada