Discovery of New Early Detection Biomarkers of Acute Respiratory Distress Syndrome
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- Analysis of serum proteins directly by proteomics analysis to identify new biomarkers of ARDS
研究概览
简要总结
The goal of this project is to find a series novel biomarkers by differential proteomic techniques that can improve the early diagnosis and develop a more efficient therapy to enhance ARDS patient survival rate.
详细描述
Acute respiratory distress syndrome(ARDS) has a very poor prognosis and high mortality. To improve the early diagnosis of ARDS, there is an urgent need for novel biomarkers of ARDS. The goal of this project is to find a series novel biomarkers by differential proteomic techniques that can improve the early diagnosis and develop a more efficient therapy to enhance ARDS patient survival rate. Clinical data and blood sample were recorded before treatment and after treatment. Acute Physiology And Chronic Health Evaluation III (APACHE III) scores were calculated at enrolment. Studying blood specimens from different period ARDS patients by proteomic analysis. It can provide information on a complex composition of proteins that are differentially expressed, which could be used for discovering high sensitivity and specificity ARDS biomarker.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The Berlin definition of acute respiratory distress syndrome
- •ATS definition of severe pneumonia
排除标准
- •age below 18 years
- •pregnancy
- •Expected survival under 24 hours
结局指标
主要结局
Analysis of serum proteins directly by proteomics analysis to identify new biomarkers of ARDS
时间窗: 1 month
次要结局
- PaO2/FiO2 ratio(baseline, day 3, day 5, 1week, 2 weeks)
- Mortality or multi-organ failure(1 month)
- APACHE III score(baseline, 1week, 2 weeks)