Mechanical Thrombectomy for Acute Large Vessel Occlusion Stroke With Mild Symptoms After Imaging Selection
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Ischemic Stroke
- Sponsor
- Shanghai East Hospital
- Enrollment
- 105
- Locations
- 1
- Primary Endpoint
- modified Rankin Scale(mRS) score of 0 to 2
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
Mechanical thrombectomy(MT) has been recommended in patients with acute large vessel occlusion stroke(LVO) , especially for those with National Institutes of Health Stroke Scale (NIHSS) score ≥6. However, it is still unclear if patients with minor strokes and LVO also benefit from MT.The aim of this study was to evaluate the safety and efficacy of MT for acute LVO and mild symptoms.
Detailed Description
This is a prospective cohort study of patients with with mild ischemic stroke (NIHSS Score \<6) and LVO. Patients were divided into 2 groups: MT or medical management.Baseline data and clinical outcomes were compared. A independent clinical outcome was defined as a modified Rankin Scale score of 0 to 2 at 90 days. A excellent clinical outcome was defined as a modified Rankin Scale score of 0 to 1 at 90 days. Symptomatic intracranial hemorrhage(sICH) was the safety outcome.
Investigators
Eligibility Criteria
Inclusion Criteria
- •acute ischemic stroke within 24 hours of symptom onset presenting cortical symptoms (such as aphasia, somnolence,slow-minded,etc.) or vertigo with bilateral pathological signs;
- •age≥18 years old;
- •the NIHSS score before evaluation of thrombectomy\<6;
- •large artery occlusion including Middle cerebral artery M1, proximal M2 segment, intracranial internal carotid artery and infarct core volume≤50ml and mismatch ratio\>1.8 or basilar artery and posterior cerebral artery P1 occlusion
Exclusion Criteria
- •Patients without prior functional independence (mRS score of \>2)
- •Patients in intervention group with occlusive artery spontaneous recanalization in digital subtraction angiography
- •patients in control group with neurological worsening and received rescue thrombectomy
Outcomes
Primary Outcomes
modified Rankin Scale(mRS) score of 0 to 2
Time Frame: 90 days
independent outcome at 90 days
Secondary Outcomes
- modified Rankin Scale(mRS) score of 0 to 1(90 days)