The effect of probiotics on depressive symptoms in depressed patients
- Conditions
- Depression
- Registration Number
- JPRN-UMIN000032825
- Lead Sponsor
- ational Center of Neurology and Psychiatry
- Brief Summary
The HAM-D21 score decreased significantly over the intervention period No statistically significant change for the percentage of subjects diagnosed with IBS. The counts of total lactobacilli and its subpopulation, Lacticaseibacillus both increased significantly after the intervention. No other bacterial targets were not significantly changed. Subgroup analyses indicated that greater exposure to Bifidobacterium and the Atopobium cluster was associated with greater reduction of depressive symptoms.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 22
Not provided
(1)Subjects who have a history of cardiovascular disease, liver disease, kidney disease, digestive tract disease and diabetes. (2)Subjects suspected to suffer from alcohol dependence and / or drug dependence. (3)Subjects who have a specific configuration that occur allergy and / or hypersensitivity against test drinks. (4)Marked suicidal ideation as indexed by three points or more on the "suicide" item of HAM-D. (5)Subjects who have edema in the brain. (6)Subjects who are diagnosed as a complication of dementia or intellectual disability. (7)Subjects who are lactating and/or pregnant. (8)Subjects who have a contraindication to MRI, such as claustrophobia, tattoo, implanted electrical device (e.g. cardiac pacemaker). (9)Those who have suffered serious head trauma or a central nervous system disease. (10)Subjects who are judged as unfit for the subject by the principal investigator
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Hamilton Depression Rating Scale(HAM-D) 2. Mini-International Neuropsychiatric Interview 3. ROME-III/ IV 4.Distribution of bacterial in feces
- Secondary Outcome Measures
Name Time Method 1. Psychometric tests 2. Plasma/Serum hormones 3. Magnetic resonance imaging