EUS Elastography for Predicting Cirrhotic-related Complications
- Conditions
- Liver Fibroses
- Registration Number
- NCT04155398
- Lead Sponsor
- Chinese University of Hong Kong
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria:<br><br> - Patients with radiologic features suggestive of cirrhosis on abdominal imaging<br> studies such as transabdominal ultrasound, CT or MRI and indication for variceal<br> screening<br><br> - Patients with suspected advanced liver fibrosis as detected by Fibroscan<br><br> - Patients with clinical evidence of hypersplenism<br><br> - Age > 18 years<br><br> - Written informed consent available<br><br>Exclusion Criteria:<br><br> - Patients with features of decompensated cirrhosis, such as history of ascites, prior<br> variceal bleeding, hepatic encephalopathy, hepatorenal syndrome<br><br> - Patients with history of hepatocellular carcinoma<br><br> - Patients with history of liver transplant or TIPS or shunting surgery<br><br> - Patients with portal and/or mesenteric vein thrombosis<br><br> - Moribund patients from terminal illnesses<br><br> - Patients with terminal malignancy<br><br> - Contraindications for endoscopy<br><br> - Unable to provide written informed consent<br><br> - Pregnancy
Not provided
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Inter-observer and intra-observer variability of liver and spleen stiffness measurements by EUS-E among endoscopists with different EUS experience;Diagnostic performance of liver and spleen stiffness measurements by EUS-E to predict variceal development and/or bleeding
- Secondary Outcome Measures
Name Time Method Diagnostic performance of liver and spleen stiffness measurements by EUS-E to predict other liver cirrhosis complications (eg, ascites, hepatic encelopathy, etc);Correlation of liver fibrosis by EUS-E to Fibroscan;Adverse events related to procedure