Assessing coronary calcium score as a non-invasive predictor of coronary artery disease severity: A comparative analysis with angiography in symptomatic and asymptomatic populations

Coronary artery disease is a major global health concern, contributing significantly to morbidity and mortality due to the build up of atherosclerotic plaque in the coronary arteries. Although coronary angiography remains the gold standard for diagnosing CAD, its invasive nature and associated risks limit its widespread use. Coronary Artery Calcium scoring, a non-invasive technique utilizing ECG gated CT, provides a safer and more cost effective approach to quantifying calcified plaque and assessing atherosclerotic burden. However, its inability to detect non-calcified plaques and challenges in monitoring disease progression, particularly in patients on statin therapy, underscore the necessity for further investigation. This study seeks to validate CAC scoring as a reliable alternative to coronary angiography, improving CAD diagnosis and management, particularly in underserved populations. By addressing its current limitations and incorporating emerging technologies, CAC scoring has the potential to revolutionize cardiovascular care and enhance patient outcomes.