Random Urine Protein-creatinin Ratio to Predict Magnitude of Proteinuria

• Conditions: Pre-eclampsia

• Registration Number: NCT01623791
• Lead Sponsor: Cukurova University

Brief Summary

The aim of this study was to evaluate diagnostic accuracy of the spot urinary proteinuria, random urine protein- creatinin ratio for prediction of significant proteinuria (≥ 300 mg/24h) and magnitude of proteinuria in patients with in mild preeclampsia and severe preeclampsia. The cross-sectional longitudinal study design used, 209 patients with pre-diagnosed preeclampsia in which in our inpatients clinic included this study. Random urine samples were taken before the 24 hour urine collection for spot urine analysis for evaluated proteinuria and protein/creatinin ratio. 24 hour urine analysis was performed in all patients as the gold standard of the urine total proteinuria.

Detailed Description

Group 1 consisted of mild preeclampsia and gestational preeclamptic patients and group 2 consisted of severe preeclamptic patients. The predictive values of the spot urinary dipstick proteinuria and protein/creatinin ratio were determinant and the correlations of the diagnostic test of 24 hour total proteinuria were evaluated. The correlations of the severity of the disease and the tests of the proteinuria were evaluated.

Study Timeline

• Study Start: 2011-05
• Status Verified: 2012-06
• Primary Completion: 2012-06
• Study Completion: 2012-06
• Study First Submitted: 2012-06-16
• Study First Submitted QC: 2012-06-19
• Last Update Submitted: 2012-06-19
• Study First Posted: 2012-06-20
• Last Update Posted: 2012-06-20

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 209

Inclusion Criteria

• 16-50 years old, > 20 gestational week pregnant women pre-diagnosed preeclampsia.
• Diagnosis and follow-up performed in inpatients clinic.

Exclusion Criteria

• The history of chronic hypertension
• The history of systemic illness such as pre-gestational diabetes, systemic lupus erythematosis , malignancies, renal disease.
• Pre-existing urinary tract infections
• Premature rupture of membranes
• Patients who have previously been enrolled in the study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prediction of significant proteinuria	24 hour urine collection	Significant proteiuria:(≥ 300 mg/24h)

Secondary Outcome Measures

Name	Time	Method
Predict to magnitude of total proteinuria	24 hour	Total proteinuria/24 hour

Trial Locations

Locations (1)

Cukurova University Faculty of Medicine; 🇹🇷 Adana, Turkey