Is a Reintervention for Pediatric Cardiac Surgery Associated With Higher Blood Transfusion Requirements ?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 2,439
- 试验地点
- 1
- 主要终点
- Transfusion of packed red cells (mL/kg)
研究概览
简要总结
In pediatric cardiac surgery, transfusion requirements are associated with age, development status, pathology, type of surgical intervention and extracorporeal bypass. In adult cardiac surgery, reinterventions (redo)are clearly linked to higher transfusion rates. The investigators want to study if this association is also true in pediatric cardiac surgery.
详细描述
Whereas in adult cardiac surgery, redo-interventions are clearly linked to a higher transfusion rate, this is not really known in paediatric cardiac surgery. In this retrospective study, the investigators will analyse our database for paediatric cardiac surgery patients aged 0-16 years and operated between 2002 and 2017. Patients with a single cardiac surgery will be compared to patients with a second cardiac operation under extracorporeal bypass. The investigators will test the variables for normal distribution using a Shapiro-Wilk test. Non normal distributed variables will be compared by a non-parametric test (Mann Whitney U), frequency analysis will be done by a Chi-Square test. A univariate analysis will determine predicting factors for transfusion. Factors with a P value < 0.1 will be analysed by a multivariate analysis to determine independent factors for transfusion. Odds with 95% confidence intervals will be calculated. A P value < 0.05 will be considered statistically significant.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- — 至 16 Years(Child)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients between 0 and 16 years
- •Cardiac surgery with cardiopulmonary bypass
排除标准
- •Jehova's witness
结局指标
主要结局
Transfusion of packed red cells (mL/kg)
时间窗: Day of operation up to 5 days postop
Transfusion requirements will be measured as volume of packed red cells given as mL packed red cells/kg of body weight
次要结局
未报告次要终点
研究者
Denis SCHMARTZ
Head of Anesthesiology department
Brugmann University Hospital
