Prediction of Hemodynamic Instability in Patients Undergoing Surgery

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)0 sites507 target enrollmentApril 1, 2015

ConditionsBlood Pressure Prediction Models Machine Learning Hemodynamic Instability

Overview

Phase: N/A
Intervention: Not specified
Conditions: Blood Pressure
Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Enrollment: 507
Primary Endpoint: Sensitivity of the HPI algorithm
Status: Completed
Last Updated: 7 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

Intraoperative hypotension occurs often and is associated with adverse patient outcomes such as stroke, myocardial infarction and renal injury.

The aim of this study was to test the accuracy of a physiology-based machine-learning algorithm using continuous non-invasive measurement of the blood pressure waveform with the Nexfin® finger cuff during surgery.

Registry

clinicaltrials.gov

Start Date

April 1, 2015

End Date

April 26, 2018

Last Updated

7 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Responsible Party

Principal Investigator

D.P.Veelo

MD PhD

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Eligibility Criteria

Inclusion Criteria

•all adult patients undergoing surgery

Exclusion Criteria

Not provided

Outcomes

Primary Outcomes

Sensitivity of the HPI algorithm

Time Frame: three minutes prior to the hypotensive event

Sensitivity

Specifity of the HPI algorithm

Time Frame: three minutes prior to the hypotensive event

Specifity

Secondary Outcomes

Predictive positive value of the HPI algorithm(15 minutes prior to the hypotensive event)
Negative predictive value of the HPI algorithm(15 minutes prior to the hypotensive event)
Sensitivity of the HPI algorithm(15 minutes prior to the hypotensive event)
Time from HPI alarm to hypotensive event during surgery(From the onset of the HPI alarm to the hypotensive event during surgery, this is in minutes. (this can range from 0,1 min to a high number such as 30 or even 40 minutes))
Specifity of the HPI algorithm(15 minutes prior to the hypotensive event)