Efficacy of combined effect of Carbocisteine in chronic sinusitis patients taking Clarithromyci
- Conditions
- Chronic Sinusitis
- Registration Number
- JPRN-UMIN000002525
- Lead Sponsor
- GETS Study Group
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 500
Not provided
1. Patients who cannot tolerate carbocisteine or clarithromycin 2. Patients who received airway disease drugs (e.g. mucolytic agents) or 14-membered macrolides within 2 weeks prior to the start of the study 3. Patients who at the start of the study were scheduled to later receive anti-inflammatory enzyme, steroids (oral, inhalation, injection, nasal spray), anti-allergic agents, or Chinese herbal medicine 4. Patients participating in other studies at the start of this study 5. Patients who have undergone radical sinus surgery 6. Patients who have undergone endoscopic sinus surgery within 12 weeks prior to the start of the study 7. Patients who have or are suspected to have paranasal mycosis 8. Patients with complications of bronchial asthma 9.Patients with history of severe cardiovascular disease 10. Patients with a complication of malignant tumor 11.Women who are or may be pregnant 12.Patients considered inappropriate by the physicians in charge
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Clinical effect (after 12 weeks)
- Secondary Outcome Measures
Name Time Method 1. SNOT-20 improvement factor 2. CT scoring 3. Clinical effect(4 weeks, 8 weeks later) 4. Subjective symptoms 5. Objective symptoms