Gastric Lavage With Paraffin Oil or Coconut Oil in Management of Acute Aluminum Phosphide Poisoning: A Randomized Controlled Clinical Trial.
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 89
- 试验地点
- 1
- 主要终点
- death
研究概览
简要总结
The aim of the present study is to evaluate safety and efficacy of gastric lavage with paraffin oil or gastric lavage with coconut oil in management of acute Aluminum phosphide poisoning.
详细描述
60 patients will be randomly assigned as control groups, paraffin group, and coconut group in a 1:1:1 ratio (30 patients in each group).
Inclusion criteria:
- Patients with symptomatic acute aluminum phosphide poisoning
- Age is more than 12 years of both gender
- Patients presenting within 6 hours post-ingestion of aluminum phosphide (Papade and Vanjari, 2019).
The diagnosis is made on the basis of:
- The suggestive clinical manifestations due to and following shortly after a single exposure to aluminum phosphide.
- Reliable identification of the compound based on the container brought by patient attendants.
- Biochemical detection of phosphine gas in gastric aspirate (silver nitrate test).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 12 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •• Patients with symptomatic acute aluminum phosphide poisoning
- •Age is more than 12 years of both gender
- •Patients presenting within 6 hours post-ingestion of aluminum phosphide
排除标准
- •• Patients less than 12 years of age
- •Pregnant and lactating women.
- •Patients with ingestion or exposure to other substances in addition to aluminum phosphide.
- •Patients with other major medical conditions (e.g. cardiovascular disease, diabetes mellitus, renal or hepatic failure).
研究组 & 干预措施
control group
gastric lavage with saline and bicarbonate and standard treatment :inotropes as levophid, fluids and electrolytes , endotracheal intubation, mechanical ventilation and antiarrhythmic agents as Magnesium sulfate
干预措施: standard treatment (Drug)
control group
gastric lavage with saline and bicarbonate and standard treatment :inotropes as levophid, fluids and electrolytes , endotracheal intubation, mechanical ventilation and antiarrhythmic agents as Magnesium sulfate
干预措施: gastric lavage with saline and bicarbonate (Other)
paraffin group
gastric lavage with paraffin oil and bicarbonate and standard treatment :inotropes as levophid, fluids and electrolytes , endotracheal intubation, mechanical ventilation and antiarrhythmic agents as Magnesium sulfate
干预措施: gastric lavage with paraffin oil and bicarbonate (Other)
paraffin group
gastric lavage with paraffin oil and bicarbonate and standard treatment :inotropes as levophid, fluids and electrolytes , endotracheal intubation, mechanical ventilation and antiarrhythmic agents as Magnesium sulfate
干预措施: standard treatment (Drug)
coconut group
gastric lavage with coconut oil and bicarbonate and standard treatment :inotropes as levophid, fluids and electrolytes , endotracheal intubation, mechanical ventilation and antiarrhythmic agents as Magnesium sulfate
干预措施: gastric lavage with coconut oil and bicarbonate (Other)
coconut group
gastric lavage with coconut oil and bicarbonate and standard treatment :inotropes as levophid, fluids and electrolytes , endotracheal intubation, mechanical ventilation and antiarrhythmic agents as Magnesium sulfate
干预措施: standard treatment (Drug)
结局指标
主要结局
death
时间窗: 72 hours
次要结局
未报告次要终点
研究者
samah maher
faculty of medicine,tanta university,Tanta Elgeesh street,qism 2,Egypt
Tanta University