Effectiveness of Intensive Light Therapy in Severely Jaundiced Sick Premature Babies
Not Applicable
- Conditions
- Health Condition 1: E806- Other disorders of bilirubin metabolism
- Registration Number
- CTRI/2021/09/036501
- Lead Sponsor
- Maulana Azad Medical College
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1) Gestational age more than or equal to 28 to less than 37 weeks, if not ascertainable, then admission weight between more than or equal to 1000 g to less than 2500 g.
2) Neonates with pathologic unconjugated hyperbilirubinemia as per NICE guidelines.
3) Postnatal age 14 days or less.
Exclusion Criteria
1) Neonates who required exchange transfusion prior to and within 24 hours of enrollment.
2) Neonates who have received phototherapy for more than or equal to 6 hours duration prior to enrollment.
3) Neonates with major congenital malformation.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Rate of change of total serum bilirubin measured as mg/dl/hour and mg/dl/hour/mg of total serum <br/ ><br>bilirubin in first 24 ± 4 hours following phototherapy initiation.Timepoint: 15 Days
- Secondary Outcome Measures
Name Time Method Duration of phototherapyTimepoint: 28 Days;Need for exchange transfusionTimepoint: 28 Days;Occurrence of acute bilirubin encephalopathy by M-BIND score.Timepoint: 28 Days;Rate of change in bilirubin albumin molar ratio (BAMR)Timepoint: 15 Days;Rate of change of total serum bilirubin measured as mg/dl/hour and mg/dl/hour/mg of total serum bilirubin until stoppage of phototherapy.Timepoint: 28 Days;Rebound in serum bilirubin at 12 ± 3 hours of discontinuation of phototherapyTimepoint: 28 Days;To evaluate the acceptability of LED intensive phototherapy by mother and staff nurses in pathological unconjugated hyperbilirubinemic unstable preterm neonates.Timepoint: 28 Days